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Robinul vs. Levsin

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Robinul and Levsin the Same Thing?

Robinul Injection (glycopyrrolate) and Levsin (hyoscyamine) are anticholinergics that help to control conditions such as peptic ulcers that involve excessive stomach acid production.

The injectable form of Robinul is also used to reduce saliva, nasal, lung, and stomach secretions and to help control heart rate during surgery.

Levsin is also used to treat different stomach and intestinal disorders, including irritable bowel syndrome. Levsin is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid.

Levsin is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease, and is also used as a drying agent to control excessive salivation, runny nose, or excessive sweating.

Side effects of Robinul and Levsin that are similar include drowsiness, dizziness, blurred vision, dry mouth, vomiting, constipation, abdominal bloating, or flushing (warmth, redness, or tingly feeling).

Side effects of Robinul that are different from Levsin include weakness, dry eyes, stuffy nose, or sinus pain.

Side effects of Levsin that are different from Robinul include nervousness, vision problems, headache, trouble sleeping (insomnia), nausea, heartburn, changes in taste, problems with urination, impotence, loss of interest in sex, trouble having an orgasm, dry skin, and decreased sweating.

Both Robinul and Levsin may interact with alcohol, amantadine, phenothiazines, or antidepressants.

Robinul may also interact with quinidine, antihistamines, decongestants, or appetite suppressants.

Levsin may also interact with antacids, haloperidol, or MAO inhibitors.

What Are Possible Side Effects of Robinul?

Common side effects of Robinul include:

  • drowsiness,
  • dizziness,
  • weakness,
  • blurred vision,
  • dry eyes,
  • dry mouth,
  • vomiting,
  • constipation,
  • abdominal bloating,
  • stuffy nose,
  • sinus pain, or
  • flushing (warmth, redness, or tingly feeling).

Tell your doctor if you experience unlikely but serious side effects of Robinul Injection including:

  • decreased sweating,
  • fast/irregular heartbeat,
  • mental/mood changes (such as confusion, hallucinations, agitation, nervousness, unusual excitement),
  • difficulty urinating, or
  • decreased sexual ability.

What Are Possible Side Effects of Levsin?

Common side effects of Levsin include:

  • dizziness,
  • drowsiness,
  • nervousness,
  • blurred vision,
  • dry mouth,
  • vision problems,
  • headache,
  • trouble sleeping (insomnia),
  • constipation,
  • nausea,
  • vomiting,
  • bloating,
  • heartburn,
  • changes in taste,
  • problems with urination,
  • impotence,
  • loss of interest in sex,
  • trouble having an orgasm,
  • flushing,
  • dry skin, and
  • decreased sweating.

Tell your doctor if you experience unlikely but serious side effects of Levsin including:

  • mental/mood changes (e.g., confusion, unusual excitement),
  • fast/irregular heartbeat,
  • loss of coordination, or
  • slurred speech.

What Is Robinul?

Robinul Injection (glycopyrrolate) is an anticholinergic that helps to control conditions such as peptic ulcers that involve excessive stomach acid production. The injectable form of Robinul is also used to reduce saliva, nasal, lung, and stomach secretions and to help control heart rate during surgery. Robinul Injection is available in generic form.

What Is Levsin?

Levsin (hyoscyamine) is one of the principal anticholinergic/antispasmodic components of belladonna alkaloids used to treat different stomach and intestinal disorders, including peptic ulcer and irritable bowel syndrome. Levsin is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. Levsin is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease, and is also used as a drying agent to control excessive salivation, runny nose, or excessive sweating. Levsin is available in generic form.

What Drugs Interact With Robinul?

Robinul may interact with amantadine, quinidine, antihistamines, decongestants, appetite suppressants, phenothiazines, or antidepressants. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy, Robinul should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Levsin?

Levsin may interact with amantadine, haloperidol, MAO inhibitors, phenothiazines, or antidepressants. Tell your doctor all medications you use. Levsin should be used only when prescribed during pregnancy. This drug passes into breast milk. Consult your doctor before breastfeeding.

How Should Robinul Be Taken?

Robinul injection is administered intramuscularly (IM) or intravenously (IV), under a physician's supervision. Dose depends on the condition being treated.

How Should Levsin Be Taken?

Dosage of Levsin for adults and children 12 years of age and older: 1 to 2 tablets every four hours or as needed. Do not exceed 12 tablets in 24 hours. Pediatric patients 2 to under 12 years of age: ½ to 1 tablet every four hours or as needed. Do not exceed 6 tablets in 24 hours.

Reviewed on 4/15/2019

SOURCE:

Mylan. Glycopyrrolate (Robinul) Product Information.

https://www.mylan.com/en/products/product-catalog/product-profile-page?id=402197af-c04e-455a-9eed-c1249f187dc7

DailyMed. Levsin Product Information.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0918c44e-54f6-47b9-b927-4f1b0b394152&audience=consumer

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