(sodium sulfacetamide 10% and sulfur 5%)
Sodium sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent. Chemically sodium sulfacetamide is N-[(4-aminophenyl)sulfonyl]-acet-amide, monosodium salt, monohydrate. The structural formula is:
Each gram of ROSANIL® (sodium sulfacetamide 10% and sulfur 5%) Cleanser contains: Active: sodium sulfacetamide 10% (100 mg), sulfur 5% (50 mg). Inactive: butylated hydroxytoluene, ede-tate disodium, emulsifying wax, hydrochloric acid, light mineral oil, methylparaben, PPG-2 hydroxyethyl coco/isostearamide, propylparaben, purified water, sodium cocoyl isethionate, sodium lauryl sulfoacetate (and) disodium laureth sulfosuccinate, and sodium thiosulfate.
DOSAGE AND ADMINISTRATION
Wash affected areas once or twice daily, or as directed by your physician. Avoid contact with eyes or mucous membranes. Wet skin and liberally apply to areas to be cleansed, massage gently into skin for 10-20 seconds working into a full lather, rinse thoroughly and pat dry. If drying occurs, it may be controlled by rinsing cleanser off sooner or using less often.
ROSANIL® (sodium sulfacetamide 10% and sulfur 5%) Cleanser is available in the following sizes:
6 oz tube NDC 0299-3839-06
13 oz tube NDC 0299-3839-13
Store at controlled room temperature
20° - 25°C (68° - 77°F).
Marketed by: Galderma Laboratories, L.P. Fort Worth, Texas 76177 USA. Manufactured by: DPT Laboratories, Ltd. San Antonio, Texas 78215 USA. www.rosanil (sodium sulfacetamide and sulfur) .com.Revised: October 2003
Although rare, sensitivity to sodium sulfacetamide may occur. Therefore, caution and careful supervision should be observed when prescribing this drug for patients who may be prone to hypersensitivity to topical sulfonamides. Systemic toxic reactions such as agranulocytosis, acute hemolyt-ic anemia, purpura hemorrhagica, drug fever, jaundice, and contact dermatitis indicate hypersensitivity to sulfon-amides. Particular caution should be employed if areas of denuded or abraded skin are involved.
FOR EXTERNAL USE ONLY. Keep away from eyes. Keep out of reach of children. Keep container tightly closed.
If irritation develops, use of the product should be discontinued and appropriate therapy instituted. Patients should be carefully observed for possible local irritation or sensitization during long-term therapy. The object of this therapy is to achieve desquamation without irritation, but sodium sulfacetamide and sulfur can cause reddening and scaling of the epidermis. These side effects are not unusual in the treatment of acne vulgaris, but patients should be cautioned about the possibility.
Carcinogenesis, Mutagenesis and Impairment of Fertility
Long-term studies in animals have not been performed to evaluate carcinogenic potential. Pregnancy: Category C. Animal reproduction studies have not been conducted with ROSANIL® (sodium sulfacetamide 10% and sulfur 5%) Cleanser. It is also not known whether ROSANIL® Cleanser (sodium sulfacetamide and sulfur) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. ROSANIL (sodium sulfacetamide and sulfur) ® Cleanser should be given to a pregnant woman only if clearly needed. Nursing Mothers: It is not known whether sodium sulfacetamide is excreted in the human milk following topical use of ROSANIL® Cleanser (sodium sulfacetamide and sulfur) . However, small amounts of orally administered sulfonamides have been reported to be eliminated in human milk. In view of this and because many drugs are excreted in human milk, caution should be exercised when ROSANIL® Cleanser (sodium sulfacetamide and sulfur) is administered to a nursing woman. Pediatric Use: Safety and effectiveness in children under the age of 12 have not been established.
No information provided.
ROSANIL® Cleanser (sodium sulfacetamide and sulfur) is contraindicated for use by patients having known hypersensitivity to sulfon-amides, sulfur or any other component of this preparation. ROSANIL® Cleanser (sodium sulfacetamide and sulfur) is not to be used by patients with kidney disease.
The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory which is based on the fact that sulfon-amides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely
unchanged. The biological half-life has variously been reported as 7 to 12.8 hours. The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.
Avoid contact with eyes, eyelids, lips and mucous membranes. If accidental contact occurs, rinse with water. If excessive irritation develops, discontinue use and consult your physician.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.