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Rutin

Osteoarthritis (OA): Treatment, Symptoms, Diagnosis

What other names is Rutin known by?

Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïdes d'Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïdes, Concentré de Bioflavonoïde, Eldrin, Extrait de Bioflavonoïde, Flavonoid, Flavonoïde, Flavonoïdes d'Agrumes, Oxerutin, Quercetin-3-rhamnoglucoside, Quercetin-3-rutinoside, Quercétine-3-rutinoside, Rutina, Rutine, Rutinum, Rutosid, Rutoside, Rutosidum, Sclerutin, Sophorin.

What is Rutin?

Rutin is a plant pigment (flavonoid) that is found in certain fruits and vegetables. Rutin is used to make medicine. The major sources of rutin for medical use include buckwheat, Japanese pagoda tree, and Eucalyptus macrorhyncha. Other sources of rutin include the leaves of several species of eucalyptus, lime tree flowers, elder flowers, hawthorn leaves and flowers, rue, St. John's Wort, Ginkgo biloba, apples, and other fruits and vegetables.

Some people believe that rutin can strengthen blood vessels, so they use it for varicose veins, internal bleeding, hemorrhoids, and to prevent strokes due to broken veins or arteries (hemorrhagic strokes). Rutin is also used to prevent a side effect of cancer treatment called mucositis. This is a painful condition marked by swelling and ulcer formation in the mouth or lining of the digestive tract.

In combination with the proteins trypsin and bromelain, rutin is also used for osteoarthritis.

Possibly Effective for...

  • Osteoarthritis. Taking rutin by mouth in combination with trypsin and bromelain seems to be about as effective as the medication diclofenac (Voltaren) in relieving pain and improving knee function in people with osteoarthritis.
  • Swelling in the arm after breast surgery (post-surgical lymphedema). Some early research suggests that taking a specific product (Wobenzym) containing rutin, pancreatin, papain, trypsin, and chymotrypsin daily for 7 weeks reduces swelling in the arm due to breast removal surgery.

Insufficient Evidence to Rate Effectiveness for...

  • Blood vessel disease.
  • Varicose veins.
  • Prevention of mouth ulcers associated with cancer treatments.
  • Bleeding.
  • Hemorrhoids.
More evidence is needed to rate the effectiveness of rutin for these uses.

Osteoarthritis (OA): Treatment, Symptoms, Diagnosis

How does Rutin work?

Rutin has chemicals that might offer some protection against cancer.

Are there safety concerns?

Rutin is LIKELY SAFE when taken by mouth in amounts found in fruits and vegetables. Rutin is POSSIBLY SAFE when taken by mouth appropriately in medicinal amounts for a short period of time. It can cause some side effects including headache, flushing, rashes, or stomach upset.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking rutin if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Dosing considerations for Rutin.

The following doses have been studied in scientific research:

BY MOUTH:
  • For osteoarthritis: 2 tablets of a combination product (Phlogenzym), which contains 100 mg of rutin, 48 mg of trypsin, and 90 mg of bromelain, 3 times daily.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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