Rybelsus vs. Trulicity

Reviewed on 12/16/2020

Are Rybelsus and Trulicity the Same Thing?

Rybelsus (semaglutide) and Trulicity (semaglutide) Injection glucagon-like peptide-1 (GLP-1) receptor agonists used as adjuncts to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Side effects of Rybelsus and Trulicity that are similar include nausea, abdominal pain, diarrhea, vomiting, and constipation.

Side effects of Rybelsus that are different from Trulicity include decreased appetite.

Both Rybelsus and Trulicity may interact with insulin secretagogues or insulin, and other oral medications taken at the same time.

What Are Possible Side Effects of Rybelsus?

Common side effects of Rybelsus include:

  • nausea,
  • abdominal pain,
  • diarrhea,
  • decreased appetite,
  • vomiting, and
  • constipation

What Are Possible Side Effects of Trulicity?

Common side effects of Trulicity include:


Type 2 Diabetes: Signs, Symptoms, Treatments See Slideshow

What Is Rybelsus?

Rybelsus (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

What Is Trulicity?

Trulicity (dulaglutide) is a human GLP-1 receptor agonist used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

What Drugs Interact With Rybelsus?

Trulicity may interact with other drugs. Tell your doctor all medications and supplements you use.

What Drugs Interact With Trulicity?

Trulicity may interact with other oral medications. Tell your doctor all medications and supplements you use.

How Should Rybelsus be Taken?

The initial dose of Rybelsus is 3 mg once daily for 30 days. After 30 days on the 3 mg dose, increase the dose of Rybelsus to 7 mg once daily.

How Should Trulicity be Taken?

The recommended initiating dose of Trulicity is 0.75 mg once weekly. The maximum recommended dose is 1.5 mg once weekly.


______________ is another term for type 2 diabetes. See Answer

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Novo Nordisk. Rybelsus Product Information.


Lilly. Trulicity Product Information.


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