Saccharomyces boulardii

What Is Saccharomyces boulardii and How Does It Work?

Saccharomyces boulardii suggested uses include for restoration of intestinal flora, post-antibiotic diarrhea, and prevention of post-antibiotic vulvovaginal candidiasis.

Saccharomyces boulardii is available under the following different brand and other names: Florastor, Florastor Kids, S. boulardii, and Saccharomyces boulardii lyo.

Dosages of Saccharomyces boulardii

Suggested Dosing

  • 1 capsule/packet orally twice daily

Dosage Considerations – Should be Given as Follows:


  • May swallow capsule whole, or empty contents of capsule or packet onto tongue followed by drinking 4 oz of water or juice
  • May also open capsule or packet and sprinkle over semisolid food (e.g., applesauce, yogurt)
  • Additionally, may open capsule or packet and dissolve contents in liquid and drink (e.g., water, juice, milk)

What Are Side Effects Associated with Using Saccharomyces boulardii?

Common side effects of Saccharomyces boulardii include:

  • Fungal infections that can spread through the bloodstream to the entire body (fungemia) (rare)

This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What Other Drugs Interact with Saccharomyces boulardii?

If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.

  • Saccharomyces boulardii has no known severe interactions with other drugs.
  • Saccharomyces boulardii has no known serious interactions with other drugs.
  • Saccharomyces boulardii has no known moderate interactions with other drugs.
  • Saccharomyces boulardii has no known mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Saccharomyces boulardii?


This medication contains Saccharomyces boulardii. Do not take Florastor, Florastor Kids, S. boulardii, or Saccharomyces boulardii lyo if you are allergic to Saccharomyces boulardii or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


Effects of Drug Abuse

  • No information available

Short-Term Effects

Long-Term Effects

  • See "What Are Side Effects Associated with Using Saccharomyces boulardii?"


Pregnancy and Lactation

  • There is no information available about use of Saccharomyces boulardii.
  • It is unknown if Saccharomyces boulardii is excreted into breast milk.
  • Pregnant or breastfeeding patients should seek advice of a health professional before using over-the-counter (OTC) drugs.

Medscape. Saccharomyces boulardii.

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