- What other names is Safflower known by?
- What is Safflower?
- How does Safflower work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Safflower.
Alazor, American Saffron, Bastard Saffron, Benibana, Benibana Oil, Benibana Flower, Cártamo, Carthame, Carthame des Teinturiers, Carthamus tinctorius, Chardon Panaché, Dyer's Saffron, Fake Saffron, False Saffron, Hing Hua, Honghua, Huile de Carthame, Kusumbha, Kusum Phool, Safflower Nut Oil, Safflower Oil, Safran Bâtard, Safranon, Zaffer, Zafran.
Safflower is a plant. The flower and oil from the seeds are used as medicine.
Safflower seed oil is used for preventing heart disease, including “hardening of the arteries” (atherosclerosis) and stroke. It is also used to treat fever, tumors, coughs, breathing problems, clotting conditions, pain, heart disease, chest pain, and traumatic injuries. Some people use it for inducing sweating; and as a laxative, stimulant, antiperspirant, and expectorant to help loosen phlegm.
In foods, safflower seed oil is used as a cooking oil.
In manufacturing, safflower flower is used to color cosmetics and dye fabrics. Safflower seed oil is used as a paint solvent.
Possibly Effective for...
- High cholesterol. Some research suggests that taking safflower oil as a dietary supplement or substituting it for other oils in the diet helps lower total and low-density lipoprotein (LDL or “bad”) cholesterol. However, it does not seem to lower other blood fats called triglycerides or raise high-density lipoprotein (HDL or “good”) cholesterol.
Possibly Ineffective for...
- Low birth weight. Some research suggests that adding a specific safflower oil product (Safola by Marico Industries Ltd.) to infant formula or breast milk does not improve weight gain or skin thickness in low birth weight infants.
Insufficient Evidence to Rate Effectiveness for...
- Cystic fibrosis. Early research shows that taking safflower oil by mouth for one year does not improve test markers or severity of cystic fibrosis in children.
- Diabetes. Early research shows that taking safflower oil by mouth for 3 weeks can increase blood glucose levels in people with type 2 diabetes. Safflower oil does not seem to affect insulin levels or insulin sensitivity.
- High cholesterol that is passed down through families (familial hypercholesterolemia). Evidence about the effects of safflower oil in treating high cholesterol that is passed down through families is conflicting. Some early research suggests that replacing dietary butter with safflower oil decrease “bad” low-density lipoprotein (LDL) cholesterol in people with this condition. Other research shows no beneficial effects.
- Hepatitis C. Early research suggests that taking a specific product containing safflower, pumpkin seeds, plantain seeds, and Japanese honeysuckle (EH0202) by mouth for 3 months reduces general discomfort, bloating, nausea, and vomiting in people with hepatitis C. However, the amount of hepatitis C virus present in the body does not appear to be affected.
- High blood pressure. Evidence about the effects of safflower oil on blood pressure is conflicting. Some early research suggests that taking safflower oil by mouth for 6-8 weeks lowers blood pressure in people with high blood pressure. However, other evidence suggests that taking safflower oil is not effective for lowering blood pressure.
- A scaly skin condition (phrynoderma). Early research suggests that taking safflower oil containing vitamin E and linoleic acid by mouth for more than 8 weeks can improve skin dryness and roughness in people with phrynoderma.
- Breathing problems (conditions that affect the breathing tubes called bronchial tubes).
- Blood circulation disorders.
- Menstrual disorders.
- Chest pain.
- Traumatic injuries.
- Other conditions.
The linolenic and linoleic acids in safflower seed oil might help prevent “hardening of the arteries,” lower cholesterol, and reduce the risk of heart disease. Safflower contains chemicals that may thin the blood to prevent clots, widen blood vessels, lower blood pressure, and stimulate the heart.
Safflower seed oil is LIKELY SAFE for most people when taken by mouth.
It is POSSIBLY SAFE to take safflower flower by mouth or to inject a specific safflower oil emulsion (Liposyn) intravenously (by IV), provided the safflower oil emulsion is administered by a healthcare professional.
Special Precautions & Warnings:Children: It is POSSIBLY SAFE to inject a specific safflower oil emulsion (Liposyn) intravenously (by IV), provided the safflower oil emulsion is administered to children by a healthcare professional.
Pregnancy and breast-feeding: Safflower seed oil is POSSIBLY SAFE to take by mouth during pregnancy. But don't take safflower flower during pregnancy. It is LIKELY UNSAFE. It can bring on menstrual periods, make the uterus contract, and cause miscarriages.
There isn't much information about the safety of using safflower seed oil or flower during breast-feeding. Stay on the safe side and avoid use.
Bleeding problems (hemorrhagic diseases, stomach or intestinal ulcers, or clotting disorders): Safflower can slow blood clotting. If you have any kind of bleeding problem, don't use safflower.
Allergy to ragweed and related plants: Safflower may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking safflower.
Surgery: Since safflower might slow blood clotting, there is a concern that it could increase the risk of bleeding during and after surgery. Stop using safflower at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Safflower oil might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, safflower oil might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Large amounts of safflower might slow blood clotting. Taking safflower along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
The following doses have been studied in scientific research:
- For high cholesterol: Safflower oil as a dietary supplement.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Abbey, M., Clifton, P., Kestin, M., Belling, B., and Nestel, P. Effect of fish oil on lipoproteins, lecithin:cholesterol acyltransferase, and lipid transfer protein activity in humans. Arteriosclerosis 1990;10(1):85-94. View abstract.
Adamkin, D. H., Radmacher, P. G., and Klingbeil, R. L. Use of intravenous lipid and hyperbilirubinemia in the first week. J Pediatr Gastroenterol.Nutr 1992;14(2):135-139. View abstract.
Al Bataina, B. A., Maslat, A. O., and Al Kofahil, M. M. Element analysis and biological studies on ten oriental spices using XRF and Ames test. J Trace Elem.Med Biol. 2003;17(2):85-90. View abstract.
Alden, P. B., Svingen, B. A., Johnson, S. B., Konstantinides, F. N., Holman, R. T., and Cerra, F. B. Partial correction by exogenous lipid of abnormal patterns of polyunsaturated fatty acids in plasma phospholipids of stressed and septic surgical patients. Surgery 1986;100(4):671-678. View abstract.
Alexander, J. W. and Gottschlich, M. M. Nutritional immunomodulation in burn patients. Crit Care Med 1990;18(2 Suppl):S149-S153. View abstract.
Anderson, J. T., Grande, F., and Keys, A. Independence of the effects of cholesterol and degree of saturation of the fat in the diet on serum cholesterol in man. Am J Clin Nutr 1976;29(11):1184-1189. View abstract.
Ando, I., Tsukumo, Y., Wakabayashi, T., Akashi, S., Miyake, K., Kataoka, T., and Nagai, K. Safflower polysaccharides activate the transcription factor NF-kappa B via Toll-like receptor 4 and induce cytokine production by macrophages. Int.Immunopharmacol. 2002;2(8):1155-1162. View abstract.
Ando, K., Nagata, K., Beppu, M., Kikugawa, K., Kawabata, T., Hasegawa, K., and Suzuki, M. Effect of n-3 fatty acid supplementation on lipid peroxidation and protein aggregation in rat erythrocyte membranes. Lipids 1998;33(5):505-512. View abstract.
Axelrod, L., Camuso, J., Williams, E., Kleinman, K., Briones, E., and Schoenfeld, D. Effects of a small quantity of omega-3 fatty acids on cardiovascular risk factors in NIDDM. A randomized, prospective, double-blind, controlled study. Diabetes Care 1994;17(1):37-44. View abstract.
Bagga, D., Anders, K. H., Wang, H. J., and Glaspy, J. A. Long-chain n-3-to-n-6 polyunsaturated fatty acid ratios in breast adipose tissue from women with and without breast cancer. Nutr Cancer 2002;42(2):180-185. View abstract.
Bagga, D., Capone, S., Wang, H. J., Heber, D., Lill, M., Chap, L., and Glaspy, J. A. Dietary modulation of omega-3/omega-6 polyunsaturated fatty acid ratios in patients with breast cancer. J Natl.Cancer Inst. 8-6-1997;89(15):1123-1131. View abstract.
Bell, E. F., Weinstein, M. R., and Oh, W. Effects of intravenously administered safflower oil emulsion on respiratory gas exchange of low-birth-weight infants. J.Pediatr.Gastroenterol.Nutr. 1983;2(3):517-520. View abstract.
Bell, S. J., Chavali, S., Bistrian, B. R., Connolly, C. A., Utsunomiya, T., and Forse, R. A. Dietary fish oil and cytokine and eicosanoid production during human immunodeficiency virus infection. JPEN J Parenter.Enteral Nutr. 1996;20(1):43-49. View abstract.
Belury, M. A., Mahon, A., and Banni, S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr 2003;133(1):257S-260S. View abstract.
Beysen, C., Belcher, A. K., Karpe, F., Fielding, B. A., Herrera, E., and Frayn, K. N. Novel experimental protocol to increase specific plasma nonesterified fatty acids in humans. Am J Physiol Endocrinol.Metab 2003;284(1):E18-E24. View abstract.
Bing, R. F., Heagerty, A. M., and Swales, J. D. Dietary changes in membrane lipids and leucocyte calcium. J Cardiovasc.Pharmacol 1988;12 Suppl 3:S110-S113. View abstract.
Bing, R. F., Heagerty, A. M., and Swales, J. D. Membrane handling of calcium in essential hypertension. J Hypertens.Suppl 1987;5(4):S29-S35. View abstract.
Bivins, B. A., Bryant, P. J., Record, K. E., Rapp, R. P., Bell, R. M., and Griffen, W. O., Jr. The effect of ten and twenty per cent safflower oil emulsion given as thirty to fifty per cent of total calories. Surg.Gynecol.Obstet. 1983;156(4):433-438. View abstract.
Bivins, B. A., Rapp, R. P., Record, K., Meng, H. C., and Griffen, W. O., Jr. Parenteral safflower oil emulsion (Liposyn 10%): safety and effectiveness in treating or preventing essential fatty acid deficiency in surgical patients. Ann.Surg. 1980;191(3):307-315. View abstract.
Bolte, M. R., Hess, B. W., Means, W. J., Moss, G. E., and Rule, D. C. Feeding lambs high-oleate or high-linoleate safflower seeds differentially influences carcass fatty acid composition. J.Anim Sci. 2002;80(3):609-616. View abstract.
Bryant, P. J., Clawson, K. D., Bivins, B. A., and Rapp, R. P. Changes in red cell membrane fatty acids in patients receiving total parenteral nutrition supplemented with a safflower oil emulsion. JPEN J.Parenter.Enteral Nutr. 1982;6(3):200-203. View abstract.
Burckart, G. J., Whitington, P. F., Halbrehder, D. K., and Helms, R. A. Triglyceride and fatty acid clearance in neonates following safflower oil emulsion infusion. JPEN J.Parenter.Enteral Nutr. 1983;7(3):251-253. View abstract.
Burton-Freeman, B., Davis, P. A., and Schneeman, B. O. Interaction of fat availability and sex on postprandial satiety and cholecystokinin after mixed-food meals. Am J Clin.Nutr. 2004;80(5):1207-1214. View abstract.
Calder, P. C., Davis, J., Yaqoob, P., Pala, H., Thies, F., and Newsholme, E. A. Dietary fish oil suppresses human colon tumour growth in athymic mice. Clin Sci (Lond) 1998;94(3):303-311. View abstract.
Challen, A. D., Branch, W. J., and Cummings, J. H. The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man. Hum Nutr Clin Nutr 1983;37(3):197-208. View abstract.
Chase, H. P., Welch, N. N., Rabaglia, M. E., and Dupont, J. Linoleic acid absorption in children with cystic fibrosis. J Pediatr Gastroenterol.Nutr 1982;1(1):49-54. View abstract.
Chiang, T. A., Wu, P. F., and Ko, Y. C. Identification of carcinogens in cooking oil fumes. Environ Res 1999;81(1):18-22. View abstract.
Ciubotaru, I., Lee, Y. S., and Wander, R. C. Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT. J Nutr Biochem. 2003;14(9):513-521. View abstract.
Clore, J. N., Stillman, J. S., Li, J., O'Keefe, S. J., and Levy, J. R. Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans. Am J Physiol Endocrinol Metab 2004;287(2):E358-E365. View abstract.
Connor, W. E. Effects of omega-3 fatty acids in hypertriglyceridemic states. Semin.Thromb.Hemost. 1988;14(3):271-284. View abstract.
Connor, W. E., DeFrancesco, C. A., and Connor, S. L. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann N.Y.Acad.Sci 6-14-1993;683:16-34. View abstract.
Connors, R. H., Coran, A. G., and Wesley, J. R. Pediatric TPN: efficacy and toxicity of a new fat emulsion. JPEN J Parenter.Enteral Nutr 1980;4(4):384-386. View abstract.
Cooke, R. J. and Burckhart, G. J. Hypertriglyceridemia during the intravenous infusion of a safflower oil-based fat emulsion. J.Pediatr. 1983;103(6):959-961. View abstract.
Cooke, R. J., Buis, M., Zee, P., and Yeh, Y. Y. Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 2. Effect on triglyceride and free fatty acid levels. J.Pediatr.Gastroenterol.Nutr. 1985;4(5):804-807. View abstract.
Cooke, R. J., Zee, P., and Yeh, Y. Y. Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 1. Effect on essential fatty acid status. J.Pediatr.Gastroenterol.Nutr. 1985;4(5):799-803. View abstract.
Coran, A. G., Drongowski, R., Sarahan, T. M., and Wesley, J. R. Comparison of a new 10% and 20% safflower oil fat emulsion in pediatric parenteral nutrition. JPEN J.Parenter.Enteral Nutr. 1981;5(3):236-239. View abstract.
Coran, A. G., Drongowski, R., Sarahan, T. M., and Wesley, J. R. Studies on the efficacy of a new 20% fat emulsion in pediatric parenteral nutrition. JPEN J Parenter.Enteral Nutr 1982;6(3):222-225. View abstract.
Cox, C., Mann, J., Sutherland, W., Chisholm, A., and Skeaff, M. Effects of coconut oil, butter, and safflower oil on lipids and lipoproteins in persons with moderately elevated cholesterol levels. J.Lipid Res. 1995;36(8):1787-1795. View abstract.
Deferne, J. L. and Leeds, A. R. Resting blood pressure and cardiovascular reactivity to mental arithmetic in mild hypertensive males supplemented with blackcurrant seed oil. J.Hum.Hypertens. 1996;10(8):531-537. View abstract.
DeLuca, P., Rossetti, R. G., Alavian, C., Karim, P., and Zurier, R. B. Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo. J Investig.Med 1999;47(5):246-250. View abstract.
Demke, D. M., Peters, G. R., Linet, O. I., Metzler, C. M., and Klott, K. A. Effects of a fish oil concentrate in patients with hypercholesterolemia. Atherosclerosis 1988;70(1-2):73-80. View abstract.
Driscoll, D. F., Giampietro, K., Wichelhaus, D. P., Peterss, H., Nehne, J., Niemann, W., and Bistrian, B. R. Physicochemical stability assessments of lipid emulsions of varying oil composition. Clin Nutr 2001;20(2):151-157. View abstract.
Driscoll, D. F., Nehne, J., Peterss, H., Klutsch, K., Bistrian, B. R., and Niemann, W. Physicochemical stability of intravenous lipid emulsions as all-in-one admixtures intended for the very young. Clin Nutr 2003;22(5):489-495. View abstract.
Dworatzek, P. D., Hegele, R. A., and Wolever, T. M. Postprandial lipemia in subjects with the threonine 54 variant of the fatty acid-binding protein 2 gene is dependent on the type of fat ingested. Am J Clin Nutr 2004;79(6):1110-1117. View abstract.
el Ashry, A., Heagerty, A. M., Ollerenshaw, J. D., and Thurston, H. The effect of dietary linoleic acid on blood pressure and erythrocyte sodium transport. J Hum Hypertens. 1989;3(1):9-15. View abstract.
Ellis, B. A., Poynten, A., Lowy, A. J., Furler, S. M., Chisholm, D. J., Kraegen, E. W., and Cooney, G. J. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol Endocrinol.Metab 2000;279(3):E554-E560. View abstract.
Epstein, M., Lifschitz, M., and Rappaport, K. Augmentation of prostaglandin production by linoleic acid in man. Clin Sci (Lond) 1982;63(6):565-571. View abstract.
Ertel, W., Morrison, M. H., Ayala, A., and Chaudry, I. H. Modulation of macrophage membrane phospholipids by n-3 polyunsaturated fatty acids increases interleukin 1 release and prevents suppression of cellular immunity following hemorrhagic shock. Arch Surg 1993;128(1):15-20. View abstract.
Espin, J. C., Soler-Rivas, C., and Wichers, H. J. Characterization of the total free radical scavenger capacity of vegetable oils and oil fractions using 2,2-diphenyl-1-picrylhydrazyl radical. J Agric.Food Chem. 2000;48(3):648-656. View abstract.
Eyjolfson, V., Spriet, L. L., and Dyck, D. J. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med Sci Sports Exerc. 2004;36(5):814-820. View abstract.
Failor, R. A., Childs, M. T., and Bierman, E. L. The effects of omega 3 and omega 6 fatty acid-enriched diets on plasma lipoproteins and apoproteins in familial combined hyperlipidemia. Metabolism 1988;37(11):1021-1028. View abstract.
Fisch, D. and Abel, R. M. Hemodynamic effects of intravenous fat emulsions in patients with heart disease. JPEN J Parenter.Enteral Nutr 1981;5(5):402-405. View abstract.
Fisher, W. R., Zech, L. A., and Stacpoole, P. W. Apolipoprotein B metabolism in hypertriglyceridemic diabetic patients administered either a fish oil- or vegetable oil-enriched diet. J Lipid Res 1998;39(2):388-401. View abstract.
Fleischman, A. I., Bierenbaum, M. L., Justice, D., Stier, A., Sullivan, A., and Fleischman, M. Titrating dietary linoleate to in vivo platelet function in man. Am J Clin Nutr 1975;28(6):601-605. View abstract.
Friday, K. E., Failor, R. A., Childs, M. T., and Bierman, E. L. Effects of n-3 and n-6 fatty acid-enriched diets on plasma lipoproteins and apolipoproteins in heterozygous familial hypercholesterolemia. Arterioscler.Thromb. 1991;11(1):47-54. View abstract.
Fuchs, G. J., Farris, R. P., DeWier, M., Hutchinson, S., Strada, R., and Suskind, R. M. Effect of dietary fat on cardiovascular risk factors in infancy. Pediatrics 1994;93(5):756-763. View abstract.
Furukawa, K., Tashiro, T., Yamamori, H., Takagi, K., Morishima, Y., Sugiura, T., Otsubo, Y., Hayashi, N., Itabashi, T., Sano, W., Toyoda, Y., Nitta, H., and Nakajima, N. Effects of soybean oil emulsion and eicosapentaenoic acid on stress response and immune function after a severely stressful operation. Ann Surg 1999;229(2):255-261. View abstract.
Ghafoorunissa, Vidyasagar, R., and Krishnaswamy, K. Phrynoderma: is it an EFA deficiency disease? Eur J Clin Nutr 1988;42(1):29-39. View abstract.
Ghoshal, A. K., Xu, Z., Wood, G. A., and Archer, M. C. Induction of hepatic insulin-like growth factor binding protein-1 (IGFBP-1) in rats by dietary n-6 polyunsaturated fatty acids. Proc.Soc.Exp Biol Med 2000;225(2):128-135. View abstract.
Gradek, W. Q., Harris, M. T., Yahia, N., Davis, W. W., Le, N. A., and Brown, W. V. Polyunsaturated fatty acids acutely suppress antibodies to malondialdehyde-modified lipoproteins in patients with vascular disease. Am J Cardiol 4-1-2004;93(7):881-885. View abstract.
Hebert, J. R., Barone, J., Reddy, M. M., and Backlund, J. Y. Natural killer cell activity in a longitudinal dietary fat intervention trial. Clin Immunol.Immunopathol. 1990;54(1):103-116. View abstract.
Helms, R. A., Herrod, H. G., Burckart, G. J., and Christensen, M. L. E-rosette formation, total T-cells, and lymphocyte transformation in infants receiving intravenous safflower oil emulsion. JPEN J.Parenter.Enteral Nutr. 1983;7(6):541-545. View abstract.
Higashi, K., Ishikawa, T., Shige, H., Tomiyasu, K., Yoshida, H., Ito, T., Nakajima, K., Yonemura, A., Sawada, S., and Nakamura, H. Olive oil increases the magnitude of postprandial chylomicron remnants compared to milk fat and safflower oil. J.Am.Coll.Nutr. 1997;16(5):429-434. View abstract.
Hodge, L., Salome, C. M., Hughes, J. M., Liu-Brennan, D., Rimmer, J., Allman, M., Pang, D., Armour, C., and Woolcock, A. J. Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children. Eur Respir.J 1998;11(2):361-365. View abstract.
Horrobin, D. F., Ells, K. M., Morse-Fisher, N., and Manku, M. S. The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: choice of an appropriate placebo for clinical studies on primrose oil. Prostaglandins Leukot.Essent.Fatty Acids 1991;42(4):245-249. View abstract.
Hubbard, V. S. and McKenna, M. C. Absorption of safflower oil and structured lipid preparations in patients with cystic fibrosis. Lipids 1987;22(6):424-428. View abstract.
Jin, Y., Xu, D., and Xu, W. [Influence of safflower injection on hemorheology of patients of chronic cor pulmonale during acute attack]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2000;20(6):430-432. View abstract.
Johnston, P., Hollenbeck, C., Sheu, W., Chen, Y. D., and Reaven, G. M. Acute changes in plasma non-esterified fatty acid concentration do not change hepatic glucose production in people with type 2 diabetes. Diabet.Med 1990;7(10):871-875. View abstract.
Kaji, K., Yoshida, S., Nagata, N., Yamashita, T., Mizukoshi, E., Honda, M., Kojima, Y., and Kaneko, S. An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C. J Gastroenterol. 2004;39(9):873-878. View abstract.
Kaminski, M. V., Jr., Abrahamian, V., Chrysomilides, S. A., Nasr, N. J., Armstrong, M. K., and Lynch, D. M. Comparative study of clearance of 10% and 20% fat emulsion. JPEN J Parenter.Enteral Nutr 1983;7(2):126-130. View abstract.
Kanehira, T., Takekoshi, S., Nagata, H., Osamura, R. Y., and Homma, T. Kinobeon A as a potent tyrosinase inhibitor from cell culture of safflower: in vitro comparisons of kinobeon A with other putative inhibitors. Planta Med. 2003;69(5):457-459. View abstract.
Kaplan, R. J., Greenwood, C. E., Winocur, G., and Wolever, T. M. Dietary protein, carbohydrate, and fat enhance memory performance in the healthy elderly. Am J Clin Nutr 2001;74(5):687-693. View abstract.
Kawashima, S., Hayashi, M., Takii, T., Kimura, H., Zhang, H. L., Nagatsu, A., Sakakibara, J., Murata, K., Oomoto, Y., and Onozaki, K. Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes. J Interferon Cytokine Res 1998;18(6):423-428. View abstract.
Kesaniemi, Y. A. and Grundy, S. M. Effects of dietary polyenylphosphatidylcholine on metabolism of cholesterol and triglycerides in hypertriglyceridemic patients. Am J Clin Nutr 1986;43(1):98-107. View abstract.
Knapp, H. R. and FitzGerald, G. A. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. N Engl J Med 4-20-1989;320(16):1037-1043. View abstract.
Kurlandsky, L. E., Bennink, M. R., Webb, P. M., Ulrich, P. J., and Baer, L. J. The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis. Pediatr.Pulmonol. 1994;18(4):211-217. View abstract.
Kwon, J. S., Snook, J. T., Wardlaw, G. M., and Hwang, D. H. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am.J.Clin.Nutr. 1991;54(2):351-358. View abstract.
Labat, J. B., Martini, M. C., Carr, T. P., Elhard, B. M., Olson, B. A., Bergmann, S. D., Slavin, J. L., Hayes, K. C., and Hassel, C. A. Cholesterol-lowering effects of modified animal fats in postmenopausal women. J Am Coll Nutr 1997;16(6):570-577. View abstract.
Liang, D. and Li, D. D. [Effect of verapamil with renal disease basic-prescription on hemorheology indexes of type II nephrotic syndrome]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(2):86-7, 68. View abstract.
Lieb, J. Linoleic acid in the treatment of lithium toxicity and familial tremor. Prostaglandins Med 1980;4(4):275-279. View abstract.
Lloyd-Still, J. D., Johnson, S. B., and Holman, R. T. Essential fatty acid status in cystic fibrosis and the effects of safflower oil supplementation. Am.J.Clin.Nutr. 1981;34(1):1-7. View abstract.
Lloyd-Still, J. D., Simon, S. H., Wessel, H. U., and Gibson, L. E. Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis. Pediatrics 1979;64(1):50-52. View abstract.
Lofgren, R. P., Wilt, T. J., Nichol, K. L., Crespin, L., Pluhar, R., and Eckfeldt, J. The effect of fish oil supplements on blood pressure. Am J Public Health 1993;83(2):267-269. View abstract.
Loo, W. T., Cheung, M. N., and Chow, L. W. The inhibitory effect of a herbal formula comprising ginseng and carthamus tinctorius on breast cancer. Life Sci. 11-26-2004;76(2):191-200. View abstract.
Lu, Z. W., Liu, F., Hu, J., Bian, D., and Li, F. G. [Suppressive effects of safflower yellow on immune functions]. Zhongguo Yao Li Xue.Bao. 1991;12(6):537-542. View abstract.
Marchildon, M. B. Parenteral 20% safflower oil emulsion safety and effectiveness as a caloric source in newborn infants. JPEN J.Parenter.Enteral Nutr. 1982;6(1):25-29. View abstract.
Mascioli, E. A., McLennan, C. E., Schaefer, E. J., Lichtenstein, A. H., Hoy, C. E., Christensen, M. S., and Bistrian, B. R. Lipidemic effects of an interesterified mixture of butter, medium-chain triacylglycerol and safflower oils. Lipids 1999;34(9):889-894. View abstract.
Mattes, R. D. Oral exposure to butter, but not fat replacers elevates postprandial triacylglycerol concentration in humans. J Nutr 2001;131(5):1491-1496. View abstract.
Mattes, R. D. Oral fat exposure alters postprandial lipid metabolism in humans. Am J Clin Nutr 1996;63(6):911-917. View abstract.
Mattes, R. D. Oral fat exposure increases the first phase triacylglycerol concentration due to release of stored lipid in humans. J Nutr 2002;132(12):3656-3662. View abstract.
Mattson, F. H. and Grundy, S. M. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J Lipid Res 1985;26(2):194-202. View abstract.
McClead, R. E., Jr., Lentz, M. E., Coniglio, J. G., Meng, H. C., and Gozs, S. The effect of three intravenous fat emulsions containing different concentrations of linoleic and alpha-linolenic acids on the plasma total fatty acid profile of neonates. J Pediatr Gastroenterol Nutr 1991;12(1):89-95. View abstract.
McClead, R. E., Jr., Meng, H. C., Gregory, S. A., Budde, C., and Sloan, H. R. Comparison of the clinical and biochemical effect of increased alpha-linolenic acid in a safflower oil intravenous fat emulsion. J.Pediatr.Gastroenterol.Nutr. 1985;4(2):234-239. View abstract.
McKenna, M. C., Hubbard, V. S., and Bieri, J. G. Linoleic acid absorption from lipid supplements in patients with cystic fibrosis with pancreatic insufficiency and in control subjects. J Pediatr Gastroenterol.Nutr 1985;4(1):45-51. View abstract.
Meselhy, M. R., Kadota, S., Hattori, M., and Namba, T. Metabolism of safflor yellow B by human intestinal bacteria. J Nat Prod 1993;56(1):39-45. View abstract.
Miller, D. G., Williams, S. K., Palombo, J. D., Griffin, R. E., Bistrian, B. R., and Blackburn, G. L. Cutaneous application of safflower oil in preventing essential fatty acid deficiency in patients on home parenteral nutrition. Am.J.Clin.Nutr. 1987;46(3):419-423. View abstract.
Mills, D. E., Galey, W. R., and Dixon, H. Effects of dietary fatty-acid supplementation on fatty-acid composition and deformability of young and old erythrocytes. Biochim.Biophys.Acta 7-4-1993;1149(2):313-318. View abstract.
Mills, D. E., Mah, M., Ward, R. P., Morris, B. L., and Floras, J. S. Alteration of baroreflex control of forearm vascular resistance by dietary fatty acids. Am J Physiol 1990;259(6 Pt 2):R1164-R1171. View abstract.
Mills, D. E., Murthy, M., and Galey, W. R. Dietary fatty acids, membrane transport, and oxidative sensitivity in human erythrocytes. Lipids 1995;30(7):657-663. View abstract.
Mischler, E. H., Parrell, S. W., Farrell, P. M., Raynor, W. J., and Lemen, R. J. Correction of linoleic acid deficiency in cystic fibrosis. Pediatr Res 1986;20(1):36-41. View abstract.
Morales, E., Craig, L. D., and MacLean, W. C., Jr. Dietary management of malnourished children with a new enteral feeding. J Am Diet Assoc 1991;91(10):1233-1238. View abstract.
Morgan, S. A., Sinclair, A. J., and O'Dea, K. Effect on serum lipids of addition of safflower oil or olive oil to very-low-fat diets rich in lean beef. J.Am.Diet.Assoc. 1993;93(6):644-648. View abstract.
Mustad, V. A., Smith, C. A., Ruey, P. P., Edens, N. K., and DeMichele, S. J. Supplementation with 3 compositionally different tocotrienol supplements does not improve cardiovascular disease risk factors in men and women with hypercholesterolemia. Am J Clin Nutr 2002;76(6):1237-1243. View abstract.
Nelson, S. E., Frantz, J. A., and Ziegler, E. E. Absorption of fat and calcium by infants fed a milk-based formula containing palm olein. J Am Coll Nutr 1998;17(4):327-332. View abstract.
Nestel, P. J. and Couzens, E. A. Influence of diet on the composition of plasma cholesterol esters in man. J Lipid Res 1966;7(4):487-491. View abstract.
Nestel, P. J., Clifton, P. M., Noakes, M., McArthur, R., and Howe, P. R. Enhanced blood pressure response to dietary salt in elderly women, especially those with small waist: hip ratio. J Hypertens. 1993;11(12):1387-1394. View abstract.
Neu, I. S. Essential fatty acids in the serum and cerebrospinal fluid of multiple sclerosis patients. Acta Neurol Scand 1983;67(3):151-163. View abstract.
Ogunleiye, A. J., Muraoka, A., Niizeki, S., Tojo, H., Hosokawa, Y., Sato, I., Tashiro, N., Urata, G., and Yamaguchi, K. Effect of fish oil and safflower oil in common Japanese diet on human plasma fatty acid composition. J.Nutr.Sci.Vitaminol.(Tokyo) 1990;36(4):423-430. View abstract.
Osaka, T., Kobayashi, A., and Inoue, S. Thermogenesis induced by osmotic stimulation of the intestines in the rat. J Physiol 4-1-2001;532(Pt 1):261-269. View abstract.
Park, Y., Jones, P. G., and Harris, W. S. Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids. Am J Clin Nutr 2004;80(1):45-50. View abstract.
Parsons, H. G., Hill, R., Pencharz, P., and Kuksis, A. Modulation of human erythrocyte shape and fatty acids by diet. Biochim.Biophys.Acta 8-21-1986;860(2):420-427. View abstract.
Peck, L. W. Essential fatty acid deficiency in renal failure: can supplements really help? J Am Diet Assoc 1997;97(10 Suppl 2):S150-S153. View abstract.
Peck, L. W., Monsen, E. R., and Ahmad, S. Effect of three sources of long-chain fatty acids on the plasma fatty acid profile, plasma prostaglandin E2 concentrations, and pruritus symptoms in hemodialysis patients. Am J Clin Nutr 1996;64(2):210-214. View abstract.
Radack, K., Deck, C., and Huster, G. The effects of low doses of n-3 fatty acid supplementation on blood pressure in hypertensive subjects. A randomized controlled trial. Arch.Intern.Med. 1991;151(6):1173-1180. View abstract.
Rahamatalla, A. B., Babiker, E. E., Krishna, A. G., and El Tinay, A. H. Changes in fatty acids composition during seed growth and physicochemical characteristics of oil extracted from four safflower cultivars. Plant Foods Hum Nutr 2001;56(4):385-395. View abstract.
Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., and Zampelas, A. Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 2003;167(2):237-242. View abstract.
Rao, R. H., Rao, U. B., and Srikantia, S. G. Effect of polyunsaturate-rich vegetable oils on blood pressure in essential hypertension. Clin Exp Hypertens. 1981;3(1):27-38. View abstract.
Richardson, T. J. and Sgoutas, D. Essential fatty acid deficiency in four adult patients during total parenteral nutrition. Am J Clin Nutr 1975;28(3):258-263. View abstract.
Robertson, D. A., Heagerty, A. M., Ollerenshaw, J. D., and Swales, J. D. Linoleic acid supplementation, membrane lipids and leucocyte sodium transport in normotensive humans. J Hum Hypertens. 1989;3(2):117-123. View abstract.
Rose, D. P., Hatala, M. A., Connolly, J. M., and Rayburn, J. Effect of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice. Cancer Res 10-1-1993;53(19):4686-4690. View abstract.
Rossetti, R. G., Seiler, C. M., DeLuca, P., Laposata, M., and Zurier, R. B. Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation. J Leukoc.Biol 1997;62(4):438-443. View abstract.
Sacks, F. M., Rouse, I. L., Stampfer, M. J., Bishop, L. M., Lenherr, C. F., and Walther, R. J. Effect of dietary fats and carbohydrate on blood pressure of mildly hypertensive patients. Hypertension 1987;10(4):452-460. View abstract.
Sacks, F. M., Stampfer, M. J., Munoz, A., McManus, K., Canessa, M., and Kass, E. H. Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport. J Am Coll Nutr 1987;6(2):179-185. View abstract.
Salerno, J. W. and Smith, D. E. The use of sesame oil and other vegetable oils in the inhibition of human colon cancer growth in vitro. Anticancer Res 1991;11(1):209-215. View abstract.
Sanders, K., Johnson, L., O'Dea, K., and Sinclair, A. J. The effect of dietary fat level and quality on plasma lipoprotein lipids and plasma fatty acids in normocholesterolemic subjects. Lipids 1994;29(2):129-138. View abstract.
Schectman, G., Kaul, S., and Kissebah, A. H. Effect of fish oil concentrate on lipoprotein composition in NIDDM. Diabetes 1988;37(11):1567-1573. View abstract.
Schectman, G., Kaul, S., and Kissebah, A. H. Heterogeneity of low density lipoprotein responses to fish-oil supplementation in hypertriglyceridemic subjects. Arteriosclerosis 1989;9(3):345-354. View abstract.
Schnell, J. W., Anderson, R. A., Stegner, J. E., Schindler, S. P., and Weinberg, R. B. Effects of a high polyunsaturated fat diet and vitamin E supplementation on high-density lipoprotein oxidation in humans. Atherosclerosis 2001;159(2):459-466. View abstract.
Simopoulos, A. P. Omega-3 fatty acids and antioxidants in edible wild plants. Biol Res 2004;37(2):263-277. View abstract.
Sircar, S. and Kansra, U. Choice of cooking oils--myths and realities. J Indian Med Assoc. 1998;96(10):304-307. View abstract.
Skolnik, P., Eaglstein, W. H., and Ziboh, V. A. Human essential fatty acid deficiency: treatment by topical application of linoleic acid. Arch Dermatol. 1977;113(7):939-941. View abstract.
Somani, P., Leathem, W. D., and Barlow, A. L. Safflower oil emulsion: single and multiple infusions with or without added heparin in normal human volunteers. JPEN J.Parenter.Enteral Nutr. 1980;4(3):307-311. View abstract.
Sosenko, I. R., Innis, S. M., and Frank, L. Menhaden fish oil, n-3 polyunsaturated fatty acids, and protection of newborn rats from oxygen toxicity. Pediatr Res 1989;25(4):399-404. View abstract.
Spann, W., Wolfram, G., and Zollner, N. [Effects of equal amounts of linoleic acid in orally administered, polyunsaturated phospholipids or in safflower oil on blood lipoproteins]. Klin.Wochenschr. 10-15-1987;65(20):980-984. View abstract.
Stacpoole, P. W., Alig, J., Kilgore, L. L., Ayala, C. M., Herbert, P. N., Zech, L. A., and Fisher, W. R. Lipodystrophic diabetes mellitus. Investigations of lipoprotein metabolism and the effects of omega-3 fatty acid administration in two patients. Metabolism 1988;37(10):944-951. View abstract.
Sutherland, W. H., De Jong, S. A., Walker, R. J., and Williams, S. M. Release of cholesterol from cell membranes to postprandial plasma from mildly hypercholesterolemic subjects: the effect of meals rich in olive and safflower oils. Metabolism 2002;51(10):1306-1312. View abstract.
Sutherland, W. H., De Jong, S. A., Walker, R. J., Williams, M. J., Murray, Skeaff C., Duncan, A., and Harper, M. Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis 2002;160(1):195-203. View abstract.
Tabrett, D. G. and Phillips, G. D. A clinical evaluation of safflower oil emulsion in total parenteral nutrition. Anaesth.Intensive Care 1982;10(3):258-264. View abstract.
Takii, T., Hayashi, M., Hiroma, H., Chiba, T., Kawashima, S., Zhang, H. L., Nagatsu, A., Sakakibara, J., and Onozaki, K. Serotonin derivative, N-(p-Coumaroyl)serotonin, isolated from safflower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibroblasts in synergy with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). J.Biochem.(Tokyo) 1999;125(5):910-915. View abstract.
Takii, T., Kawashima, S., Chiba, T., Hayashi, H., Hayashi, M., Hiroma, H., Kimura, H., Inukai, Y., Shibata, Y., Nagatsu, A., Sakakibara, J., Oomoto, Y., Hirose, K., and Onozaki, K. Multiple mechanisms involved in the inhibition of proinflammatory cytokine production from human monocytes by N-(p-coumaroyl)serotonin and its derivatives. Int Immunopharmacol. 2003;3(2):273-277. View abstract.
Turner, J. D., Le, N. A., and Brown, W. V. Effect of changing dietary fat saturation on low-density lipoprotein metabolism in man. Am J Physiol 1981;241(1):E57-E63. View abstract.
Ulrich, H., Pastores, S. M., Katz, D. P., and Kvetan, V. Parenteral use of medium-chain triglycerides: a reappraisal. Nutrition 1996;12(4):231-238. View abstract.
Vaidya, U. V., Hegde, V. M., Bhave, S. A., and Pandit, A. N. Vegetable oil fortified feeds in the nutrition of very low birthweight babies. Indian Pediatr 1992;29(12):1519-1527. View abstract.
van der Willigen, A. H., van Joost, T., Stolz, E., and van der Hoek, J. C. Contact dermatitis to safflower. Contact Dermatitis 1987;17(3):184-186. View abstract.
Wardlaw, G. M., Snook, J. T., Lin, M. C., Puangco, M. A., and Kwon, J. S. Serum lipid and apolipoprotein concentrations in healthy men on diets enriched in either canola oil or safflower oil. Am.J.Clin.Nutr. 1991;54(1):104-110. View abstract.
Wells, D. H., Ferlauto, J. J., Forbes, D. J., Graham, T. R., Newell, R. W., Wareham, J. A., and Wilson, C. A. Lipid tolerance in the very low birth weight infant on intravenous and enteral feedings. JPEN J Parenter.Enteral Nutr 1989;13(6):623-627. View abstract.
Wilson, J. H., Rietveld, T., Van den Berg, J. W., Jansen, H., Swart, G. R., and Lamberts, S. W. The effect of very low energy diets on the fatty acid composition of serum lipids. Int J Obes. 1989;13 Suppl 2:51-60. View abstract.
Wilt, T. J., Lofgren, R. P., Nichol, K. L., Schorer, A. E., Crespin, L., Downes, D., and Eckfeldt, J. Fish oil supplementation does not lower plasma cholesterol in men with hypercholesterolemia. Results of a randomized, placebo-controlled crossover study. Ann Intern Med 12-1-1989;111(11):900-905. View abstract.
Wong, K. H. and Deitel, M. Studies with a safflower oil emulsion in total parenteral nutrition. Can.Med.Assoc.J. 12-15-1981;125(12):1328-1334. View abstract.
Wong, S. H., Nestel, P. J., Trimble, R. P., Storer, G. B., Illman, R. J., and Topping, D. L. The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver. Biochim.Biophys.Acta 2-9-1984;792(2):103-109. View abstract.
Wretlind, A. Development of fat emulsions. JPEN J Parenter.Enteral Nutr 1981;5(3):230-235. View abstract.
Yaqoob, P., Pala, H. S., Cortina-Borja, M., Newsholme, E. A., and Calder, P. C. Encapsulated fish oil enriched in alpha-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. Eur J Clin Invest 2000;30(3):260-274. View abstract.
Zhang, H. L., Nagatsu, A., Watanabe, T., Sakakibara, J., and Okuyama, H. Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) oil cake. Chem Pharm Bull (Tokyo) 1997;45(12):1910-1914. View abstract.
Zhang, Q., Peng, J. H., and Zhang, X. N. [A clinical study of Safflower Yellow injection in treating coronary heart disease angina pectoris with Xin-blood stagnation syndrome.]. Chin J Integr.Med 2005;11(3):222-225. View abstract.
Zucker, M. L., Bilyeu, D. S., Helmkamp, G. M., Harris, W. S., and Dujovne, C. A. Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. Atherosclerosis 1988;73(1):13-22. View abstract.
Abraham RD, Riemersma RA, Elton RA, et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. Atherosclerosis 1990;81:199-208. View abstract.
Amato, P. and Quercia, R. A. A historical perspective and review of the safety of lipid emulsion in pregnancy. Nutr Clin Pract. 1991;6(5):189-192. View abstract.
Borkman M, Chisholm DJ, Furler SM, et al. Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 1989;38:1314-9.. View abstract.
Cox C, Sutherland W, Mann J, et al. Effects of dietary coconut oil, butter and safflower oil on plasma lipids, lipoproteins and lathosterol levels. Eur J Clin Nutr 1998;52:650-4. View abstract.
Francois CA, Connor SL, Wander RC, Connor WE. Acute effects of dietary fatty acids on the fatty acids of human milk. Am J Clin Nutr 1998;67:301-8. View abstract.
Herbel BK, McGuire MK, McGuire MA, Shultz TD. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am J Clin Nutr 1998;67:332-7. View abstract.
Higdon JV, Du SH, Lee YS, et al. Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. J Lipid Res 2001;42:407-18. View abstract.
Higdon JV, Liu J, Du S, et al. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)- isoprostanes. Am J Clin Nutr 2000;72:714-22. View abstract.
Hwang DH, Chanmugam PS, Ryan DH, et al. Does vegetable oil attenuate the beneficial effects of fish oil in reducing risk factors for cardiovascular disease? Am J Clin Nutr 1997;66:89-96. View abstract.
Ishikawa T, Fujiyama Y, Igarashi O, Morino M, Tada N, Kagami A, Sakamoto T, Nagano M, and Nakamura H. Effects of gammalinolenic acid on plasma lipoproteins and apolipoproteins. Atherosclerosis 1989;75:95-104. View abstract.
Jiang ZM, Zhang SY, Wang XR, et al. A comparison of medium-chain and long-chain triglycerides in surgical patients. Ann Surg 1993;217:175-84. View abstract.
la Vecchia C, Negri E, Franceschi S, et al. Olive oil, other dietary fats, and the risk of breast cancer (Italy). Cancer Causes Control 1995;6:545-50. View abstract.
Li D, Sinclair A, Wilson A, et al. Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. Am J Clin Nutr 1999;69:872-82. View abstract.
Melancon SB, Vanasse M, Geoffroy G, et al. Oral lecithin and linoleic acid in Friedreich's ataxia: II. Clinical results. Can.J Neurol.Sci 1982;9:155-64. View abstract.
Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. View abstract.
Pang D, Allman-Farinelli MA, Wong T, et al. Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. Br J Nutr 1998;80:163-7. View abstract.
Reiser R, Probstfield JL, Silvers A, et al. Plasma lipid and lipoprotein response of humans to beef fat, coconut oil and safflower oil. Am J Clin Nutr 1985;42:190-7. View abstract.
Shi M, Chang L, He G. [Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus]. Zhongguo Zhong Yao Za Zhi 1995;20:173-5, 192. View abstract.
Smith, D. E. and Salerno, J. W. Selective growth inhibition of a human malignant melanoma cell line by sesame oil in vitro. Prostaglandins Leukot Essent Fatty Acids 1992;46(2):145-150. View abstract.