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SAPHO Syndrome (cont.)

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What is the outlook (prognosis) for patients with SAPHO syndrome?

To some degree, the outlook for patients with SAPHO syndrome is not predictable but depends on response to medications. When sulfasalazine or methotrexate quiet the symptoms and signs of inflammation, the outlook is optimal.

Can SAPHO syndrome be prevented?

Because the tendency toward developing SAPHO syndrome is inherited, it is not possible to prevent the disease at this time.

Medically reviewed by Kirkwood Johnston, MD; American Board of Internal Medicine with subspecialty in Rheumatology


Klippel, John H., et al., eds. Primer on the Rheumatic Diseases. 13th ed. New York: Springer and Arthritis Foundation, 2008.

Medically Reviewed by a Doctor on 11/18/2015



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