Radiculopathy: Any disease of the spinal nerve roots and spinal nerves. Radiculopathy is characterized by pain that seems to radiate from the spine, extending outward to cause symptoms away from the source of the spinal nerve root irritation. Causes of radiculopathy include deformities of the discs between the vertebrae. Patients with diabetes can be affected by a form of radiculopathy that may be caused by inadequate blood supply to the spinal nerve roots. Also known as radiculitis.