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Definition of Peroxisome proliferator-activated receptor

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Peroxisome proliferator-activated receptor: A member of the nuclear hormone receptor subfamily of transcription factors. Peroxisome proliferator-activated receptor is abbreviated as PPAR.

There are 3 known subtypes of PPARs -- PPAR-alpha, PPAR-delta, and PPAR-gamma. The gene for PPAR-gamma is in chromosome band 3p25. It regulates the development of adipocytes (fat cells).

PPAR-gamma also influences the prenatal survival of dizygotic (nonidentical) twins. Twins with the same type of PPAR-gamma may develop at the same pace. However, when the twins are carrying different versions of PPAR-gamma, one twin may develop at the expense of the other.

Reviewed on 12/11/2018

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