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Definition of Hypocitraturia

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Hypocitraturia: a low level of citrate in the urine. A level of urine citrate of less than 320 mg/day is typically classified as low, but in severe cases, excretion of citrate can be less than 100 mg/day. Low urine citrate levels are a risk factor for kidney stone formation because citrate inhibits the process of calcium stone formation. There are a number of causes of low urine citrate and calcium kidney stone formation, including gout, urinary tract infection, certain medications, high animal protein consumption, and distal renal tubular acidosis, among others. Hypocitraturia is estimated to be involved in about 1/3 of those who have calcium kidney stones. Treatment with potassium citrate is successful at resolving the hypocitraturia in most patients.

Reviewed on 12/21/2018

REFERENCE: MedscapeReference. Hypocitraturia.

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