The 10 Most-Prescribed and Top-Selling Medications

By Troy Brown, RN
WebMD Health News

Reviewed by Michael W. Smith, MD

May 8, 2015 -- The thyroid drug Synthroid continues to be the nation's most-prescribed medication. But Humira, which treats a variety of conditions, had the highest sales, according to the research firm IMS Health.

The firm released data on the top 100 prescriptions and sales from April 2014 through March 2015.

Synthroid (levothyroxine), which treats hypothyroidism, or underactive thyroid disease, has been the top-prescribed medicine for several years.

Humira (adalimumab), which treats conditions including arthritis and Crohn's disease, overtook last year's best-seller, Abilify (aripiprazole).

The top 10 medications by number of monthly prescriptions are:

  1. Synthroid (levothyroxine), 21.5 million
  2. Crestor (rosuvastatin), 21.4 million
  3. Ventolin HFA (albuterol), 18.2 million
  4. Nexium (esomeprazole), 15.2 million
  5. Advair Diskus (fluticasone), 13.7 million
  6. Lantus Solostar (insulin glargine), 10.9 million
  7. Vyvanse (lisdexamfetamine), 10.4 million
  8. Lyrica (pregabalin), 10.0 million
  9. Spiriva Handihaler (tiotropium), 9.6 million
  10. Januvia (sitagliptin), 9.1 million

The top 10 meds by sales are:

  1. Humira (adalimumab), $8.2 million
  2. Abilify (aripiprazole), $7.9 million
  3. Sovaldi (sofosbuvir), $6.9 million
  4. Crestor (rosuvastatin), $5.9 million
  5. Enbrel (etanercept), $5.9 million
  6. Harvoni (ledipasvir and sofosbuvir), $5.3 million
  7. Nexium (esomeprazole), $5.3 million
  8. Advair Diskus (fluticasone), $4.7 million
  9. Lantus Solostar (insulin glargine), $4.7 million
  10. Remicade (infliximab), $4.6 million

You can see the complete list of the top 100 in each category on Medscape.


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