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Definition of Cholestasis

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Cholestasis: a decrease or blockage in the flow of bile. Bile is a fluid produced by the liver that travels through ducts to enter the digestive system in the small intestine. Diseases of the liver, pancreas, or of the bile ducts themselves can all cause cholestasis. Symptoms of cholestasis include jaundice (yellowing of the skin and whites of the eyes look yellow), dark urine, itching, and light-colored stool.

Reviewed on 8/9/2018

REFERENCE: Jameson, JL, et al. Harrison's Principles of Internal Medicine, 20th ed. (Vol.1 & Vol.2). McGraw-Hill Education 2018.

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