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Definition of Alzheimer's disease

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Alzheimer's disease: A progressive degenerative disease of the brain that leads to dementia. On a cellular level, Alzheimer's disease is characterized by the finding of unusual helical protein filaments in nerve cells of the brain. These twisted filaments are called neurofibrillary tangles. In the brain, Alzheimer's disease involves degeneration of the cortical regions, especially the frontal and temporal lobes. There is currently no cure for Alzheimer's disease, but new medications and therapies appear to slow its progress and improve the patient's ability to function.

Reviewed on 12/4/2018

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