TLR4 is a transmembrane lipopolysaccharide receptor. Activation of it causes the release of antimicrobial peptides, inflammatory cytokines and chemokines, and costimulatory molecules that initiate the innate immune response to common gram-negative bacteria. TLR4 also interacts with respiratory syncytial virus, heat-shock proteins, fibronectin, fibrinogen, and hyaluronic acid.
Reviewed on 12/11/2018
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