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Definition of MEF2A

MEF2A: A transcription factor that participates in vascular development. MEF2A is a member of the myocyte enhancer factor-2 (MEF2) family of transcription factors. Messenger RNA (mRNA) from MEF2A has been detected in blood vessels during early embryogenesis. The gene for MEF2A is located on chromosome 15q26.

A heritable deletion within the MEF2A gene that results in the loss of 7 amino acids appears responsible for an autosomal dominant form of coronary artery disease. The deletion alters the cellular distribution of the MEF2A protein and may prevent its function as a vascular transcription factor. It remains to be seen if the MEF2A pathway plays a role in the common form of coronary artery disease resulting from atherosclerosis.

MEF2A is also known as MADS box transcription enhancer factor 2, polypeptide A.

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