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Definition of Isoform

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Isoform: A protein that has the same function as another protein but which is encoded by a different gene and may have small differences in its sequence. For example, transforming factor beta (TGF-B) exists in three versions, or isoforms (TGF-B1, TGF-B2, and TGF-B3), each of which can set off a signaling cascade that starts in the cytoplasm and terminates in the nucleus of the cell.

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Reviewed on 12/21/2018

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