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Definition of STS

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

STS: Commonly used abbreviation for "sequence tagged site." A short (200 to 500 base pair) DNA sequence that occurs but once in the genome and whose location and base sequence are known.

STSs are detectable by polymerase chain reaction (PCR), are useful for localizing and orienting the mapping and sequence data, and serve as landmarks on the physical map of a genome.

Expressed sequence tags (ESTs) are STSs derived from cDNAs (complementary DNAs).

Reviewed on 12/27/2018

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