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Definition of C-reactive protein

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

C-reactive protein: An acute-phase plasma protein whose blood concentration reflects the presence and intensity of inflammation. Abbreviated CRP. Conditions that commonly lead to marked increases in CRP include infection, trauma, surgery, burns, inflammatory conditions, and advanced cancer. Moderate changes occur after strenuous exercise, heatstroke, and childbirth. Small changes occur after psychological stress and in several psychiatric illnesses. Elevated levels of CRP are associated with atherosclerosis and heart disease.

Reviewed on 12/27/2018

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