Comment from: Joy 65-74 Transgender less than 1 month Caregiver Published: October 06

Makes you so nauseated! And abdominal cramps! And so expensive!

Comment from: Margaret 55-64 Transgender less than 1 month Caregiver Published: July 08

Amitiza did not help with my constipation; quite the opposite I became even more bound up, bloated and in intestinal pain. I also was unable to go to sleep and developed pain in the middle of my chest. Even if this medication did help me, a fate I so very much wished, I would not continue due to the exhorbitant daily cost.

Related Reading: amitiza | constipation

Comment from: goatzool 65-74 Transgender less than 1 month Caregiver Published: May 22

I tried Amitiza for IBS-C 8 years ago, but on an as-needed basis. It usually worked at 16 mcg, but the next day there was rebound constipation and I was reluctant to take it daily (largely because of the expense). Now I've been through them all and the doctor wants me to try Lubiprostone (now generic) on a regular 2x per day basis. Oddly, it is not as effective now as it was 8 years ago. I am going to try combining it with Miralax, which is apparently an option for colonoscopy prep. The bottom line seems to be that no laxative ever works predictably except (for me) mag cit, and it's a bad idea to take that daily.

Related Reading: amitiza | constipation | miralax

Comment from: Northwest 75 or over Female 1 to less than 2 years Patient Published: January 05

Have M.S. and IBS. After much trial and error: my best daily regimen: Take 1 cap full Miralax in 10 oz hot water or coffee before breakfast. Take 1 8 mg capsule Amitiza with breakfast. Results in 2 hours. May need liquid glycerin suppository when you have urge to go. Dose of 8 mg Amitiza every morning is sufficient. Recommend sticking to a regular schedule but don't worry if you miss a day.

Related Reading: miralax | amitiza

Comment from: Jim 55-64 Male Patient Published: July 19

Expensuve junk that made my poo like peanut butter. Mirlax works and is cheaper than $320 a month.

Comment from: Will I Ever 'Go' Again? 55-64 Female less than 1 month Patient Published: June 30

Doctor gave samples. Within 1 hour I got nauseated, hot all over, chest tight and lungs burning with tiny deep breath, felt 'bad' all over, heart pounding and anxious. Oh...and I had a bowel evacuation (only moderate) but was feeling so bad I needed to lay down. I can't take this stuff ever again. I was incidentally poisoned 10 years ago and the symptoms are the same. I wonder if it has any benzene or formaldehyde in it?

Comment from: Frustrated 55-64 Female 1 to 6 months Patient Published: April 22

Gave me deadly Diarrhea with horrible dehydration. 1 of the most horrible laxatives I have ever taken.

Related Reading: diarrhea | dehydration

Comment from: None 55-64 Female 1 to 6 months Patient Published: December 01

It makes you go just a little tiny bit without control about every 20 minutes like 8 or more times all day. Thatâ??s only taking it once instead of twice a day and 8 mcg. I canâ??t trust to leave the house. It cost $250 a month, so I will not be taking it again. It makes your poop mucousy. Awful drug. Gave me cramps and an abdominal ache too. Iâ??ll take fiber or Senokot or anything else before I waste money feeling sick again. I have gastroparesis so the GI doctor told me I needed it but didnâ??t warn me about the awful effects.

Related Reading: gastroparesis

Comment from: OPBMC 55-64 Female 5 to less than 10 years Patient Published: May 29

My IBS-C symptoms are not as severe as many reviews that I have read. I do not have any pain associated with my diagnosis and my constipation could be handled with OTC remedies. My issue is with severe bloating and the Amitiza does not effectively relieve these symptoms. I started at 8mcg per meal, now I'm regularly at 24mcg per meal and still no relief from the bloating. Even knowing what my trigger foods are I can't avoid all of them because they're the most healthy foods to eat.

Related Reading: constipation | amitiza

Comment from: John 45-54 Male 1 to 6 months Patient Published: May 12

I’ve tried EVERYTHING for IBS-C and either the medication caused diarrhea or didn’t work at all. I keep track of my water intake, I exercise, and watch what I eat, too. This drug is a total game changer. I take the small dose twice per day (and I’m a 210 lb guy) and it works perfectly. Normal BM 2-3 times per day, no more bloating, no more gas, and no side effects (for me, at least). Seriously, the only downside is the enormous price.

Related Reading: diarrhea

Comment from: Jz 65-74 Female 1 to 6 months Patient Published: April 24

Still drinking smooth move tea while on the med. Random results. Still days between BM. Terrible swelling and excruciating pain in hands and feet. Was on med and quit when I was in so much pain and not eating. When I was up, moving and eating for 2 days and no BM, I started the med. after 3 days it started all over. NO MORE. Not worth the agony.

Comment from: 55-64 Male 1 to less than 2 years Patient Published: February 13


Comment from: In pain 45-54 Female 1 to less than 2 years Patient Published: December 22

I was put on the 24mg dosage and after 3-4 hours of being uncomfortable, I had a good b.m. I thought this was going to be great until about an hour later. I had diarrhea 9 times during the day and could not leave my house because a few times I almost didn't make it the 12 steps to the bathroom. I tried it again a few days later and it was a repeat of the first day. I was switched to 8mg and for 3 days it was great, but then it didn't work. I now use the 24 when I feel so bad I cannot go another day. I always plan to do nothing for 24 hours!

Related Reading: diarrhea

Comment from: sarosata steve 65-74 Female 2 to less than 5 years Patient Published: July 17

As a Type 1 diabetic with GI autonomic neuropathy and gastroparesis, I have been on Amitiza 8mcg for over 2 years. It is the only medication which gives me relief, but it takes several hours after ingestion to effect a movement. It is difficult to leave the house until that happens. The cost of the medication is outrageous and my insurance stopped covering any of the cost. Also, it is not approved for males at the 8mcg dose. Linzess side effects were worse which is why I was switched to Amitiza. For me, the 24mcg dose would be too much. Not sure what to do in the future, as few doctors handle diabetic neuropathy of the GI system. I have been a type 1 diabetic for 28 years and I don't expect my symptoms to improve on their own without medication.

Related Reading: gastroparesis | amitiza | linzess

Comment from: Lighthousegirl 35-44 Female 1 to 6 months Patient Published: April 16

I've been on this medication for 2 months. After reading all reviews and experiencing side effects, I'm going to stop taking it. I have following side effects: difficulty breathing, chest tightness, gas, insomnia, mood swings. Side effects not worth the benefit of this medication (it's hasn't been effective for me at all).

Related Reading: insomnia

Comment from: 45-54 Female less than 1 month Patient Published: March 17

I wasn't having BM for at least 14 days. Went on the meds and now I have severe diarrhea every day. I go at least 5 times a day. Want to be taken off this!

Related Reading: diarrhea

Comment from: Shira 35-44 Female less than 1 month Patient Published: November 19

I have been using this for two weeks and feel like hell!! I have severe nausea depression and terrible headaches and for the ibs and constipation it barely help!!!

Related Reading: depression | constipation

Comment from: cvdixon29 35-44 Male 6 months to less than 1 year Patient Published: October 24

At first it worked great, then it seemed to almost stop working. However, I believe it just takes time for your body to get use to it. It took a while for it work well. So Far it's working great! I'm very please. I go almost daily now instead of once per week! I feel better.


You are constipated if you don't have a bowel movement every day. See Answer
Comment from: Silent Wolf 35-44 Female 6 months to less than 1 year Patient Published: October 22

My doctor gave me 24mcg samples for OIC and the resulting anal fissures. We tried daily, but it worked TOO well, if you catch my drift. We switched to every other day and that's working well.

Comment from: 55-64 Female 1 to 6 months Patient Published: September 19

works well in spurts. makes intestinal track always moist and expels mucous. not comfortable. still have to use other laxatives and they seem to work less since use of this drug.


Medical Editor: John P. Cunha, DO, FACOEP

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