Related Drug Monograph: Prometrium oral See All User Reviews on WebMD and Submit Your Own Review Comment from: 1stDayReaction 45-54 Transgender less than 1 month Caregiver Published: August 04 Had been taking 150mg compounded progesterone for months to treat hot flashes and sleep interruptions during menopause. Switched to 50 mg compounded and 100mg Prometrium. 1st dose was AWFUL. Within 30 minutes I felt drunk. I could barely walk. Next day I had a migraine and my stomach was bloated and uncomfortable and I was very fatigued. Prior to this, I had taken a different brand of progesterone as well as the compounded progesterone and had no side effects. I don't know what's in this drug, but it is definitely not good for my body. Related Reading: hot flashes | prometrium Comment from: concerned 55-64 Transgender 5 to less than 10 years Caregiver Published: July 04 This pill is round and rubbery. It is difficult to swallow. It gets stuck in my throat and has blocked my wind pipe so I had a hard time breathing, It's very painful. I tried everything to swallow it with water, food and it still stays lodged in the throat or wind pipe, I have to cough it up as it doesn't dissolve. It works wonders but the swallowing is difficult for me and wish they could redesign the shape of the pill. Comment from: Judy Diamond 65-74 Transgender less than 1 month Caregiver Published: June 08 I started taking Prometrium in conjunction with Esdtradot 2 days ago. The side effects of Prometrium are horrible; dizziness, very tired, so what is the point of them at all? With so many nasty side effects listed, why bother to promote this product to women who are already going through the pains and misery of menopause? Related Reading: prometrium | dizziness Comment from: Hone 45-54 Female less than 1 month Patient Published: February 29 This medication gave me severe insomnia and upset my stomach. Related Reading: insomnia Comment from: 35-44 Female 1 to 6 months Patient Published: September 14 I've been in surgical menopause since 2013 with horrible side effects from the estrogen only treatment. This medicine has given me my life back. I am finally able to sleep all night. No more depression or anxiety. I feel normal now. Related Reading: treatment | depression | anxiety Comment from: Normal Again 55-64 Female 1 to less than 2 years Patient Published: August 16 I was suffering from severe, frequent hot flashes. My doctor prescribed 100 mg vaginally at bedtime. Soon, my flashes subsided and I was also sleeping a lot better. A year later, she put me on DHEA and I slowly decreased the Prometrium without recurrence of the hot flashes. Related Reading: hot flashes | prometrium Comment from: 45-54 Female 2 to less than 5 years Patient Published: June 15 I started taking this medication 4 years ago. I am pre-menopausal and it really helps with the mood swings, anxiety levels, hot flashes and sleeping (mostly) I have severe insomnia. My periods were never normal so I can't really speak about that side of things. But I am really glad the doctor prescribe this. Related Reading: anxiety | hot flashes | insomnia Comment from: MB 45-54 Female 2 to less than 5 years Patient Published: April 19 Helps with sleep, stops night sweats and night time anxiety, helps control excess bleeding. Sometimes, seems as if a batch might not be as effective as previous, but overall, this stuff has been a lifesaver for me. My endometrial biopsies are back to normal after taking this for almost 2 years. I plan to continue taking this just about forever. It is good to take it at night because it does make you drowsy, but that is a benefit for me. Related Reading: night sweats | anxiety Comment from: GoingToSeed 45-54 Female 6 months to less than 1 year Patient Published: March 11 I am going to be 50 in a few weeks and have been taking prometrium for about 6 months. The peri-menopausal period of my life has been hell until prometrium. Now I no longer have the horrendous heavy bleeding (from 7 days to 3 days) and clots or extended bleeding anymore every 2 weeks. My ferritin and iron levels have normalize and I feel human again. I love this hormone replacement. Related Reading: prometrium Comment from: Sheila 45-54 Female less than 1 month Patient Published: March 06 I took first dose and became so dizzy and light headed. I barely made it to the couch. I either passed out or fell asleep. Had serious cramps and very sleepy over next 24 hours. Comment from: Maryann 45-54 Female 6 months to less than 1 year Patient Published: December 05 I love it have been taking it for about 19 months and all abnormal cell growth is gone and I feel like a new woman....dizzy is the only side affect and since it is a bedtime drug it don't bother me..... Comment from: cleigh14 25-34 Female 1 to 6 months Patient Published: August 11 I've been on this for 2 months and have experienced depression and severe mood swings, spotting (although the doctor was trying to convince me there's nothing to worry about with the spotting...the whole point of me taking this drug is so that I can get pregnant and sustain a pregnancy because I have super low progesterone levels; spotting is really terrifying to see when you're trying to get pregnant and think you're having a miscarriage), and tiredness. I think my doctor has no idea what she's doing. Related Reading: depression | pregnancy | miscarriage Comment from: 45-54 Female 2 to less than 5 years Caregiver Published: May 13 This pill is very round and difficult to swallow. It stays stuck in my throat and is very painful. I tried everything to swallow it with water, food and it still stays lodged in the throat for the whole day until it dissolves. Too bad because it works wonders but the swallowing is difficult for me Comment from: ms 25-34 Female less than 1 month Patient Published: November 04 I take it at supper time. I get drowsy and dizzy. I'm glad I chose to take this during a time where I don't have to travel. I can deal with it as long as I continue taking in evenings. So far, I have seen little to no change in my bleeding. I have taken this 7 days as of 11/4/14. Comment from: Cynthia7678 35-44 Female 1 to 6 months Patient Published: September 10 Been on for a month, going to try a three month regiment . Help with dysfunctional vaginal bleeding , pre menopausal . No side effects, feel better , symptoms going away. Love this , feel I handle handle my life again. Related Reading: vaginal bleeding Comment from: 45-54 Female less than 1 month Patient Published: January 21 I am peri-menopausal and had very heavy bleeding for a month. I was so anemic (red cell count 64) I needed an emergency blood transfusion. Thought the bleeding was due to menopause but an ultrasound revealed a fibroid. I rested for 2 weeks, am taking iron & 200 mg of prometrium at night. My bleeding stopped immediately, I have been advised to take it for 3 months until a followup appt. where it may be decided that I get a hysterectomy. I am concerned because I now have slight retinal ischemia in both eyes, caused by my anemia, and am worried that the prometrium may make it worse. Basically worried about blood clots though not sure if I need to be? Related Reading: prometrium | blood clots Comment from: Kristig0404 35-44 Female less than 1 month Patient Published: December 22 This stuff is poison! Went on it per my dr for Pms symptoms/ low progesterone. Within 4 days I was having severe panic/anxiety attacks, depression, and lethargy. Please think twice about using this as I am on day 8 off of it and still having panic, depression, and lethargy Related Reading: anxiety | depression QUESTION What is pelvic inflammatory disease (PID)? See Answer Comment from: Ruth 65-74 Female 10 years or more Patient Published: November 30 I am post menopausal and taking one 50mg prometrium capsule in the evening before bedtime. The idea is to protect my uterine lining while I use an estrogen patch to protect my bones from osteoporosis. I have taken nearly every form of progesterone over the last 10 years and cannot tolerate any of it. My muscles and joints ache; I become progressively more irritable: I experience nausea and intestinal bloating, plus I bleed and have night sweats. Overall, I consider this medicine to be highly toxic to my body and without much benefit, if any. Related Reading: prometrium | osteoporosis | night sweats From Women's Conditions Resources How Much Period Pain Is Normal? Self-Care Tips for Facial Psoriasis Is Your Skin Trouble Blocked Hair Follicles? Featured Centers Good and Bad Foods for PsoriasisVideo: Getting Personal on Life With MS Health Solutions From Our Sponsors Shot-Free MS Treatment Your Child and COVID-19 References Pharmacy Editor: Eni Williams, Pharm.D., Ph.D.