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Comment from: LisaC-NNY, 35-44 on Treatment for 6 months - 1 year (Patient) Published: September 20

Provigil has been WONDERFUL. For the past seven years I have been fighting to find out what is wrong with me. All I wanted to do was sleep, I felt awful. The first doctor called it depression and I tried three different SRIs before taking prozac for 4 years. About 1-1/2 years ago I decided to wean off the prozac. I felt I was missing my life. I wasn't the me I missed. I found another doctor, and because I am also always in a lot pain - I was living on excedrine -(made up of tylenol & asprin for the pain, and caffine to keep me moving), we did alot tests. She said due to high virus markers I had chronic fatigue. I also believe it's fibromalagia but we haven't discussed it yet). I almost cried telling her I felt like I'd missed the last 5-7 years of my children's lives because I was always so tired and in pain. She asked if I wanted to try provigil. I would have tried anything. I HAVE MY LIFE BACK! I've been taking it for about 6 months now and I feel like ME again. I don't just want to lay down and sleep after lunch at work and I don't come home and fall asleep on the couch like before. I get things done. I ENJOY doing all kinds of things with my kids and I don't feel like I'm paying for it physically when I do. This medicine seems to help with the pain and maybe the migraines too. I am amazed at how I can think now - no fog. I JUST FEEL SO MUCH BETTER! (I do still ached somewhat but not like before!) I went to this site to see what others felt about it becasue I didn't know it was going to help with the pain and was wondering just what this miracle drug was. Thanks for your reviews - it inspired me to share. I take 100mg a day at 6am and by 9-10pm I'm ready for sleep. IT HAS TRULY CHANGED MY LIFE!! I HAVE a life again!

Related Reading: provigil | depression | prozac

Comment from: elw, 45-54 on Treatment for 2-5 years (Patient) Published: December 31

After 3 nighttime sleep studies, 2 of which also included daytime sleep studies, the final conclusion was that I suffered from "Excessive Daytime Sleepiness Disorder". All I knew was that I was fighting hard to keep up my successful career, and it seemed to be getting harder all the time. According to my dr, Excessive Daytime Sleepiness Disorder runs in families, and I can see it in certain of my family members. I just did not have the energy or brainpower to keep up with work and home, and no amount of sleep seemed to help me shake it. I knew something was really wrong because when I traveled, and upon boarding a plane, I would put my carry-ons up, sit down, and the next thing I knew, we were in the air. Provigil gave me my life back. I've been taking it for over 2 years now. As far as I can tell, I've suffered no adverse reactions. If I forget to take my next dose, my brain lets me know when it has run out of steam. But as long as I take my doses as prescribed, I am fully functioning all day long. Power of concentration is back, grogginess is gone, and I have energy to do more than just veg out. This is a miracle drug for me!

Comment from: None, 45-54 on Treatment for 1-6 months (Patient) Published: November 01

I rotate Provigil with Amantadine and Ritalin for the fatigue I have from my MS. It lasts about a year before I have to start again with one of the other ones. They all last about 1 year before I become immune or they are not as effective as they started out. It has been a godsend for me. It helps me focus and stay alert. I like what it does for me, so does my husband, not so tired all the time.

Related Reading: amantadine | ritalin | fatigue

Comment from: annie, 45-54 on Treatment for 5-10 years (Patient) Published: June 13

PROVIGIL GAVE ME MY LIFE BACK. I haved suffered from major chronic depression since my teens that caused me to lose years of productivity as my doctors struggled to find the right anti-depressants, mood-stablilizers, anti-psychotics, etc... There is hardly any on this entire list I haven't been on. After 10 years of intensive in-patient and out patient drug and psychotherapy I finally became stable enough to go back to work. BUT, the drugs made me too sleepy to work and my doctor wasn't about to put me on the true "speedy" meds after all my bouts with overdoses. I started Provigil 6 months before I returned to work and I am back leading a full life again. I have been back at my original career (teaching) for 6 years. The first 2 years my doctor provided me with all the free samples expecting the FDA approval we were bitterly dissappointed when that didn't happen. My insurance started giving us all kinds of trouble after it wasn't approved for other problems. Like most people i cannot afford $750+ for one medicine. What you can do is have your doctor order a sleep study and then when he/she shows proof that you have had a sleep study done the insurances usually relent. I don't know what I would do without this drug. I would still be sitting at home watching the world go by. I hope that one day the FDA would listen to those of us this drug has helped and have used it responibly to improve our quality of life and in very good cases, like mine, even go back to work and feel like the professional i was trained to be.

Related Reading: provigil | teens

Comment from: [email protected], 35-44 on Treatment for 5-10 years (Patient) Published: December 21

I have been using Provigil for about 6 years now. I have been liviving with MULTIPLE SCLEROSIS for about 10 years now. About 6 years ago I was fighting really bad FATIGUE! I have been on Provigil ever sence then. I feel it has worked for me very well!!, It has been very easy for me to use!!!, Yes I have been satisfied with the overall experience with Provigil. I really don't know how I would do with out it.? TAUSHA~

Related Reading: multiple sclerosis | fatigue

Comment from: M.S. sleepy, 35-44 on Treatment for 1-6 months (Patient) Published: August 02

I have MS & in am tired & sleep a lot. I take 200mg & I'm awake but still have some tired feelings we tried 300mg & it works GREAT. I can think a lot better actually function. I have been reading about the cost call the manufacturer & they have programs for help with copays or the whole cost. All medications have these programs. Also if you web surf there is a lot of programs out there with help pay for medications. I hope this helps.

Comment from: chelseigh, 25-34 on Treatment for 2-5 years (Patient) Published: November 19

I have Multiple Sclerosis and chronic fatigue is a major problem as is being able to focus since we just we feel "cloudy" sometimes is the best way I can describe it. The first day I took this pill I was ecstatic at how good it made me feel. I was able to focus, I had enough energy to clean my house and most important of all just being able to get out of bed. I recommend this to people if your doc finds it appropiriate. My hardest time was when I had to come off of it due to pregnancy and then nursing my baby. I am happy that I am able to take it again. My neurologist who has MS himself takes it as well. I hope anyone who takes it has the same experience.

Related Reading: multiple sclerosis | fatigue | pregnancy

Comment from: Nikki w/MS, 45-54 on Treatment for 5-10 years (Patient) Published: January 10

May 2003.After 2 other meds. had failed for my MS fatigue; I finally found Provigil.Now, Jan 2010, I take 1 in the morning & 1 mid-day. Thank God for Provigil.

Related Reading: provigil

Comment from: Suffering in silence in Sacramento, CA, 55-64 on Treatment for 1-6 months (Patient) Published: June 03

I have been suffering from Chronic Fatigue Immune Dysfunction Syndrome since 1995. I am disabled from working and have lost pretty much my life and friends etc. Feb. 2011 I was given Provigil at my request. And it was wonderful. I could not believe how the "brain fog" simply disappeared. Now I asked for a refill in May, 2011 and was told my Insurance Co. won't cover cost. Are you kidding me? Finally, we find something to give my life back to me and the insurance company basically says no, we want you to continue to suffer!!!!!!!!! Tramadol was given prior to Provigil and it works great too! However, it seems to become less effective much faster and you need more and more. I don't like that part! I do not want to become addicted. How can we avoid it when we need something to treat a "chronic" condition? It is sad that the health care system is more concerned about how much it costs to care for us than helping us live full, satisfying lives. Where do I go from here? The hopelessness returns. Thanks for nothing Health Net!!!!!!!!!!!!!!!

Related Reading: fatigue | tramadol

Comment from: 25-34 on Treatment for less than 1 month (Patient) Published: September 01

I have Fibromyalgia and with that came severe fatigue all day, memory loss, and severe lack of motivation. Because of this I was in fear that I may lose my job because I didm't want to get out of bed. I have been taking Provigil for only a week now but it has chnged my life. I am alert motivated and ready to go to work every morning. My memory has improved and I no longer have severe pain and I am no longer "fuzzy headed" all the time. I also sleep like a baby at night! I feel like a new person!

Related Reading: fibromyalgia

Comment from: joeinbham, 35-44 Female on Treatment for 2-5 years (Patient) Published: July 16

I was given this medication to try in hopes of relieving 30 years of chronic intractable depression. Provigil was prescribed and the Lexipro dose I take was lowered by half. The result was nothing short of a miracle for me. I would even go on to say that it cured my depression completely. Now, all of my hopes and dreams in life are possible. Where as before, I had almost given up due to my chronic depression and countless attempts to keep my focus and mood up due to my depression. I am 44 now and feel like I just started to really live 3 years ago. I have a great psychiatrist, therapist, family, friends and God to thank for getting me to that day 3 years ago. I could never have dreamed that I would be doing the things I do today in a happy and consistent way.

Related Reading: depression

Comment from: sue, 55-64 on Treatment for 1-6 months (Patient) Published: September 27

For years I struggled with what my doctor thought was depression - and I was exhausted, occurring every 2 months or so - I would hardly be able to get out of bed. Once I used Provigil, it went away. I have some sleep apnea (had sleep study done), but the fatigue has gone away during the day, and I don't wake up feeling like I got "hit with a hammer" - and no depression.

Related Reading: sleep apnea

Comment from: Narcolepsy, 25-34 on Treatment for less than 1 month (Patient) Published: April 19

I am currently prescribed Provigil for Narcolepsy. At first the dosage that I was given was working great, however half-way through the month it seems as though my body has gotten use to it and it is not working as it did in the beginning. My doctor stated that this is typical and after 30 days the dosage is increased. I wanted to let anyone having issues with insurance companies covering this medication that if your doctor calls your insurance company and states that this is the only medication that will work for your condition; the insurance company will cover their cost of the medication. I have United HealthCare and this is what needed to be done in my case. There are also other organizations out there, if you do not have insurance, to cover the cost of specific prescriptions like Provigil.

Related Reading: provigil | narcolepsy

Comment from: S.jaros, 45-54 on Treatment for 1-6 months (Patient) Published: March 02

I have had daytime sleepiness my whole life but now I am 47 and it has really become a problem. I have no apnea and can easily sleep 10 hours a night. A one or two hour nap is always welcome as well. Some people would kid me that I was lazy and that sleep is my favorite past time. Well, it is my favorite past time but I'm not lazy. I have 3 kids, two part-time jobs, a beautiful bayfront house and I go to the gym 5 days a week. I am at a healthy weight. What people don't understand is how hard it is to go through the day feeling like you're walking through mud. Yawning-sluggish-just wanting to..that's right-go to bed! Provigil has at least helped me stay awake during the day. I can still sleep 10 hours a night but at least I can skip the daytime naps. I have been prescribed 200 mg. a day but am taking 300-I will call my dr. next week and let him know I have uped the dosage. I have seen no funky side-effects. I would definatly recommend this especially to women who have to run a household, have small kids, ect. It's at least worth a try. Life is no fun when all you want to do is sleep.

Comment from: Pauli74, 35-44 on Treatment for 1-2 years (Patient) Published: June 17

I started taking this for excessive tiredness during the day. I was constantly falling asleep in while driving etc. At first I had massive headaches about mid afternoon everyday but over time they went away. Now, I wouldn't trade this for anything. I am able to stay awake when needed but can still nap if I have time. I finally feel normal!

Comment from: ggma, 55-64 on Treatment for 1-2 years (Patient) Published: December 30

I have cronic fatigue with fibromyalgia. this make me alert and active all day!

Related Reading: fatigue | fibromyalgia

Comment from: marie, 65-74 on Treatment for 2-5 years (Patient) Published: November 27

I had chronic fatigue after a Lyme-type disease, then stopped walking, got depressed, gained weight, and got breast cancer. Treated with two surgeries and had radiation-related fatigue. I am a nurse who had experience with cancer patients who took Provigil, and asked to try it. My M.D. prescribed it three years ago. I found it to be the best thing for me. I had tried various antidepressants but got many side effects. Unlike antidepressants,Provigil/Modafinal can be taken as needed, and works immediately, so I have tapered off of the daily dose (it does stop working after a while,) and use 50 mg. two or three times a week, or as needed. If I overdo it I get heart palpitations and headaches. What a miracle, I have my health back. I don't feel anxious that I'll get depressed because I can't make it through the day. I walk and eat well. My insurance didn't cover it til after I had radiation. This is a good drug for me, and my doctor agrees. I am careful not to overuse it!

Related Reading: breast cancer | cancer | antidepressants

Comment from: mamagl, 45-54 on Treatment for 6 months - 1 year (Patient) Published: November 17

Provigil has been very good for me. I've been suffering with chronic pain for many many years, so I'm on pain medications for many years also. Which lead to constant sleepiness & sometime I can't even tell what day it is, cause I've been sleeping for days. Only reason I'm waking is can't bear the pain even I'm sleeping & because pain is so bad I can't reach pain pills. Finally I've spoke to my doctor about sleeping problem, because I've felt it's not worth living, when all I'm doing is nothing but sleeping & taking pain pills. My doctor gave me PROVIGIL to try out & next morning I've felted like a new person. I was up about 10hrs & my mine was so clear, I could take care of my check book. Hallelujah!!!! Since then I've been doing very well. Except, my biggest problem is wonderful " INSURANCE Co.s". Because I don't have "Narcolepsy" they denied every time. So, now I'm paying it out of my little Disability check I'm receiving & it's very expensive, but lease I can leave like almost normal person, instead sleep my life away. Thank God for Provigil, even though I have less money.

Related Reading: chronic pain

Comment from: rheeah7, 45-54 on Treatment for less than 1 month (Patient) Published: September 23

I have cfs with severe spine and disc problems. Between pain and exaustion what I normally feel is very extreme. I have just started 100mg of the Provigil and have already felt the difference. I have been alert, able to complete tasks and even got out in my garden. Although I overdid it, I felt great getting outside. I have learned to take it very early in A.M. as the later I take it the longer I am up at night. 8am should be the latest time to take the med. I will make sure I monitor myself with smart breaks, but overall I feel mentally and physically better. This is amazing. If this is something that may not last, I am going to enjoy this time and put it to good use.

Related Reading: provigil

Comment from: Judy, 45-54 on Treatment for 5-10 years (Patient) Published: November 27

I was put on this for my fatigue, I was sooo tired through out the day, I had problems mentally, and physically. This is my life saver..but... and it is a big is o EXPENSIVE, don't know if I can afford to stay on it... so I'm going to do some research, and see if there might be something else I can use.

Related Reading: fatigue

Comment from: so grateful, 65-74 on Treatment for 1-2 years (Patient) Published: June 27

For me, this medication has been a miracle. I normally have no motivation to get things done, even enjoyable activities. But, when I take Provigil, I have motivation to do anything I want to... from work to fun things. I no longer have to fight with myself to keep from wanting to sleep all day. I take this medication for depression. But since it is not FDA approved for depression, I have to pay out of pocket, and have to order it out of the country because in the USA it is only approved for ADD, sleep apnea, shift work, and narcalepsy. Never the less, I am so grateful to have it. I no longer dread each day, and it has had nothing but good effects on my life.

Related Reading: depression | sleep apnea

Comment from: Accountant, 55-64 Female on Treatment for 5-10 years (Patient) Published: December 29

Take provigil for extreme debilitating fatigue during day. I take 200mg tablet once a day early enough that it won't keep me awake at night. Super results without narcotic type euphoria. Been taking for six years. Because of the cost $10/pill) and insurance refusal to recognize effectiveness and refusal to pay for drug, I only take provigil once every 4 or 5 days. Strange reactions from doctor regarding drug. Some think it's effective; another might think it's narcotic-like and addictive. No addiction here.

Related Reading: provigil

Comment from: ktonelli00, 45-54 on Treatment for less than 1 month (Patient) Published: September 21

It has been a long time since I have felt this awake. I have so much more energy. It is unreal how much better I feel after only a few days on this medication. I can't sit still I want to do so much. This is a wonderful medication. It has given me hope. After so many years of being tired all the time.

Comment from: MS Fatigued , 45-54 on Treatment for 2-5 years (Patient) Published: June 22

I was taking this RX for fatigue resulting from Multiple Sclerosis. My insurance company is now declining appeals by my neurologist to prescribe this medicine because the FDA does not show that it benefits people with my disease. I have been benefiting from taking this RX for 4 years and am now being told there is no benefit by the FDA and my insurance company. When initially prescribed this RX MS was a 'condition' for this RX. I don't think the decision making 'bodies' at the FDA take into consideration those that live with chronic fatigue understand that we have no advocate nor resource when they make these decisions that change peoples lives. What about quality of life for the member / patient? Why do 'they' get that power. The FDA does not publish the ethics of why they change or update their PDRs; where is the administration of drug use without that on behalf of the member / patient.

Related Reading: multiple sclerosis

Published: December 12

Used for 3 months for chronic MS fatigue (2 months of free samples, 1 prescibed). Stopped taking because there is no generic and it is very costly. 200mg/day worked great for me but have recently switched to Amantadine because there is a generic and it is less expensive.

Related Reading: amantadine

Medical Editor: John P. Cunha, DO, FACOEP

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