Rocephin (ceftriaxone sodium) and Cipro (ciprofloxacin) are antibiotics used to treat many kinds of bacterial infections. Rocephin is also used to treat severe or life-threatening infections such as meningitis. Rocephin and Cipro are different types of antibiotics. Rocephin is a cephalosporin antibiotic and Cipro (ciprofloxacin) is a quinolone antibiotic.