Triamcinolone Cream vs. Mupirocin CreamSource: RxList VersusTriamcinolone acetonide cream and mupirocin cream are topical medications used to treat skin conditions. Triamcinolone acetonide cream is used to relieve skin inflammation, itching, dryness, and redness. Mupirocin cream is indicated for the treatment of secondarily infected traumatic skin lesions due to susceptible isolates of Staphylococcus aureus and Streptococcus pyogenes.