Sectral Side Effects Center

Last updated on RxList: 7/18/2022
Sectral Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Sectral?

Sectral (acebutolol hydrochloride) is a beta-blocker used to treat hypertension (high blood pressure) and heart rhythm disorders. Sectral is available in generic form.

What Are Side Effects of Sectral?

Common side effects of Sectral include:

  • dizziness,
  • lightheadedness,
  • drowsiness,
  • tiredness,
  • slow heartbeat,
  • anxiety,
  • nervousness,
  • constipation,
  • diarrhea,
  • stomach upset/gas,
  • nausea,
  • trouble sleeping (insomnia), or
  • unusual dreams your body adjusts to the medication.

Other side effects of Sectral include decreased sex drive, impotence, or difficulty having an orgasm. Tell your doctor if you have serious side effects of Sectral including:

  • symptoms of asthma (feelings of tightness in the chest, shortness of breath, cough, wheezing),
  • blue fingers or toes,
  • fainting,
  • very slow heartbeat,
  • new or worsening symptoms of heart failure (such as swelling ankles or feet, severe tiredness, shortness of breath, unexplained/sudden weight gain),
  • mental/mood changes (such as confusion, depression, memory problems),
  • vision changes, or
  • symptoms of liver disease (such as dark urine, persistent nausea, vomiting, stomach or abdominal pain, or yellowing eyes or skin).

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Sectral

The initial dosage of Sectral in uncomplicated mild-to-moderate hypertension is 400 mg. The usual initial dose of Sectral to treat ventricular arrhythmia is 400 mg daily given as 200 mg twice daily.

What Drugs, Substances, or Supplements Interact with Sectral?

Sectral may interact with allergy treatments (or if you are undergoing allergy skin-testing), clonidine, guanabenz, MAO inhibitors, diabetes medications, heart medications, medicines for asthma or other breathing disorders, cold medicines, stimulant medicines, or diet pills. Tell your doctor all medications and supplements you use.

Sectral During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant during treatment with Sectral; it is not expected to be harmful to a fetus. Sectral can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Sectral (acebutolol hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Sectral Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • new or worsening chest pain;
  • slow heartbeats;
  • a light-headed feeling, like you might pass out; or
  • dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats.

Common side effects may include:

  • headache, dizziness;
  • feeling tired;
  • nausea, upset stomach;
  • diarrhea, constipation; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Sectral (Acebutolol)


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Sectral Professional Information


Sectral is well tolerated in properly selected patients. Most adverse reactions have been mild, not required discontinuation of therapy, and tended to decrease as duration of treatment increases.

The following table shows the frequency of treatment-related side effects derived from controlled clinical trials in patients with hypertension, angina pectoris, and arrhythmia. These patients received Sectral, propranolol, or hydrochlorothiazide as mono therapy, or placebo.


Body System/
Adverse Reaction
(N=1002) %
(N=424) %
(N=178) %
(N=314) %
Chest Pain 2 4 4 1
Edema 2 2 4 1
Central Nervous System
Depression 2 1 3 1
Dizziness 6 7 12 2
Fatigue 11 17 10 4
Headache 6 9 13 4
Insomnia 3 6 5 1
Abnormal dreams 2 3 0 1
Rash 2 2 4 1
Constipation 4 2 7 0
Diarrhea 4 5 5 1
Dyspepsia 4 6 3 1
Flatulence 3 4 7 1
Nausea 4 6 3 0
Micturition (frequency) 3 1 9 <1
Arthralgia 2 1 3 2
Myalgia 2 1 4 0
Cough 1 1 2 0
Dyspnea 4 6 4 2
Rhinitis 2 1 4 <1
Special Senses
Abnormal Vision 2 2 3 0

The following selected (potentially important) side effects were seen in up to 2% of Sectral patients:

Cardiovascular: hypotension, bradycardia, heart failure.

Central Nervous System: anxiety, hyper/hypoesthesia, impotence.

Dermatological: pruritus.

Gastrointestinal: vomiting, abdominal pain.

Genitourinary: dysuria, nocturia.

Liver and Biliary System: A small number of cases of liver abnormalities (increased SGOT, SGPT, LDH) have been reported in association with acebutolol therapy. In some cases increased bilirubin or alkaline phosphatase, fever, malaise, dark urine, anorexia, nausea, headache, and/or other symptoms have been reported. In some of the reported cases, the symptoms and signs were confirmed by rechallenge with acebutolol. The abnormalities were reversible upon cessation of acebutolol therapy.

Musculoskeletal: back pain, jointpain.

Respiratory: pharyngitis, wheezing.

Special Senses: conjunctivitis, dry eye, eye pain.

Autoimmune: In extremely rareinstances, systemic lupus erythematosus has been reported.

The incidence of drug-related adverse effects (volunteered and solicited) according to Sectral dose is shown below. (Data from 266hypertensive patients treated for 3 months on a constant dose.)

Body System 400 mg/day
800 mg/day
1200 mg/day
Cardiovascular 5% 2% 1%
Gastrointestinal 3% 3% 7%
Musculoskeletal 2% 3% 4%
Central Nervous System 9% 13% 17%
Respiratory 1% 5% 6%
Skin 1% 2% 1%
Special Senses 2% 2% 6%
Genitourinary 2% 3% 1%

Potential Adverse Events

In addition, certain adverse effects not listed above have been reported with other β-blocking agents and should also be considered as potential adverse effects of Sectral.

Central Nervous System: Reversible mental depression progressing to catatonia (an acute syndrome characterized by disorientation for time and place), short-term memory loss, emotional lability, slightly cloudedsensorium, and decreased performance(neuropsychometrics).

Cardiovascular:Intensification of AV block (see CONTRAINDICATIONS).

Allergic: Erythematousrash, fever combined with aching and sore throat, laryngospasm, and respiratorydistress.

Hematologic: Agranulocytosis, nonthrombocytopenic, and thrombocytopenic purpura.

Gastrointestinal: Mesenteric arterial thrombosis and ischemic colitis.

Miscellaneous: Reversiblealopecia and Peyronie's disease. The oculomucocutaneous syndrome associated with the β-blocker practolol has not been reported with Sectral during investigational use and extensive foreign clinical experience.


Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with β-blocking agents. Patients treated with Sectral plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia. Exaggerated hypertensive responses have been reported from the combined use ofβ-adrenergic antagonists and α-adrenergic stimulants, including those contained in proprietary cold remedies andvasoconstrictive nasal drops. Patients receiving β-blockers should be warned of this potential hazard.

Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non steroidal anti-inflammatory drugs has been reported.

No significant interactions with digoxin, hydrochlorothiazide, hydralazine, sulfinpyrazone, oral contraceptives, tolbutamide, or warfarin have been observed.

Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.

Read the entire FDA prescribing information for Sectral (Acebutolol)

© Sectral Patient Information is supplied by Cerner Multum, Inc. and Sectral Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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