How Do Selective Inhibitors of Nuclear Export Work?

Reviewed on 11/9/2021

HOW DO SELECTIVE INHIBITORS OF NUCLEAR EXPORT WORK?

Selective inhibitors of nuclear export (SINE) are a class of drugs used to treat multiple myeloma (a type of cancer of the bone marrow) and diffuse large B-cell lymphoma (a type of cancer that begins in the white blood cells) in patients who have previously been treated with at least one other medication.

SINE compounds are anti-cancer medications that work by blocking the action of a protein called chromosome region maintenance 1 or exportin. This blockage further leads to inhibition of transport of several proteins involved in cancer cell growth from the cell nucleus to the cytoplasm that eventually leads to cell cycle arrest and apoptosis (the death of cells which occurs as a normal and controlled part of an organism's growth or development).

SINE compounds are administered via oral route, typically once or twice a week with or without food.

HOW ARE SELECTIVE INHIBITORS OF NUCLEAR EXPORT USED?

Selective inhibitors of nuclear export are used to treat multiple myeloma in combination with bortezomib and dexamethasone. They are also used to treat diffuse large B-cell lymphoma.

WHAT ARE SIDE EFFECTS OF SELECTIVE INHIBITORS OF NUCLEAR EXPORT?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

Understanding Cancer: Metastasis, Stages of Cancer, and More See Slideshow

WHAT ARE NAMES OF SELECTIVE INHIBITORS OF NUCLEAR EXPORT?

Generic and brand names of selective inhibitors of nuclear export include:

References
https://reference.medscape.com/drugs/selective-inhibitors-of-nuclear-export-sine

https://www.webmd.com/drugs/2/drug-177518/selinexor-oral/details

https://medlineplus.gov/druginfo/meds/a619044.html

https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-refractory-or-relapsed-multiple-myeloma

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200201/

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