How Does Selective Uric Acid Reabsorption Inhibitor (SURI) Work?

Reviewed on 1/21/2022

How does selective uric acid reabsorption inhibitor (SURI) work?

Selective uric acid reabsorption inhibitor (SURI) is a class of medication prescribed for excessive uric acid in the blood (hyperuricemia) associated with gout, a painful arthritic condition. Uric acid is a waste product from the metabolism of purine, an essential chemical in the body. SURI reduces blood uric acid levels by promoting its excretion in the urine.

Gout is caused by excess uric acid getting deposited as monosodium urate crystals in joints, bones, and soft tissues, which induces an immune reaction, leading to inflammation and associated symptoms. Gout most commonly affects the big toes, but can also affect other joints such as ankles, knees, elbows, wrists, and fingers.

Selective uric acid reabsorption inhibitor inhibits the activity of urate transporter URAT1 which is responsible for uric acid reabsorption in the kidneys. SURI also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia.

Selective uric acid reabsorption inhibitor may be combined with a xanthine oxidase inhibitor, another class of medication commonly used to treat gout. Xanthine oxidase inhibitor reduces uric acid production by inhibiting the activity of xanthine oxidase, an enzyme that synthesizes uric acid from hypoxanthine, a purine derivative.

Currently, the selective uric acid reabsorption inhibitor is no longer available in the market because its production has been discontinued by the manufacturer.

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How is selective uric acid reabsorption inhibitor (SURI) used?

Selective uric acid reabsorption inhibitor (SURI) is administered as oral tablets, approved by the FDA for use in the following conditions:

  • Hyperuricemia
  • Gout

What are side effects of selective uric acid reabsorption inhibitor (SURI)?

Side effects of selective uric acid reabsorption inhibitor (SURI) may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What are names of selective uric acid reabsorption inhibitor (SURI)?

Generic and brand names of the FDA-approved selective uric acid reabsorption inhibitor (SURI) and its combination with xanthine oxidase inhibitor include:

QUESTION

Gout is a form of arthritis. See Answer
References
https://reference.medscape.com/drugs/selective-uric-acid-reabsorption-inhibitor-suri

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