Medical Editor: John P. Cunha, DO, FACOEP
What Is Sermorelin Acetate?
Sermorelin acetate is a human growth hormone-releasing hormone (GHRH or GRF) used for diagnostic evaluation of pituitary function and also for increasing growth in children. Off label usage of sermorelin acetate may include acute or age-related growth hormone insufficiency. Sermorelin acetate is discontinued; generic versions may be available.
What Are Side Effects of Sermorelin Acetate?
Sermorelin Acetate may cause serious side effects including:
- injection site reaction (pain, swelling or redness),
- difficulty breathing, and
- swelling of the face, mouth, lips or tongue
Get medical help right away, if you have any of the symptoms listed above.
Common side effects of sermorelin acetate include:
- injection site reactions (such as pain, swelling, or redness),
- difficulty swallowing,
- changes in taste,
- pale skin (pallor), or
- tightness in the chest.
Seek medical care or call 911 at once if you have the following serious side effects:
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Dosage for Sermorelin Acetate
A dosage of 0.2 - 0.3 mg of sermorelin acetate once daily at bedtime by subcutaneous injection is recommended.
What Drugs, Substances, or Supplements Interact with Sermorelin Acetate?
Sermorelin acetate may interact with glucocorticoids. Tell your doctor all medications and supplements you use.
Sermorelin Acetate During Pregnancy or Breastfeeding
During pregnancy, sermorelin acetate should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our sermorelin acetate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
A large proportion of patients develop anti- GRF antibodies at least once during treatment with Sermorelin. The significance of these antibodies is not clear and often a positive test at one growth assessment will become negative by the next assessment. The presence of antibodies does not appear to affect growth or appear to be related to a specific adverse reaction profile. No generalized allergic reactions to Sermorelin have been reported.
The most common treatment-related adverse event (occurring in about 1 patient in 6) is local injection reaction characterized by pain, swelling or redness. Of 350 patients exposed to Sermorelin in clinical trials, three discontinued therapy due to injection reactions. Other treatment-related adverse events had individual occurrence rates of less than 1% and include: headache, flushing, dysphagia, dizziness, hyperactivity, somnolence and urticaria.
When administered intravenously for diagnostic use, the following adverse reactions have been noted: flushing of the face, injection site pain, redness and/or swelling, nausea, headache, vomiting, dysgeusia, pallor and tightness in the chest.
Drug Abuse and Dependence
The clinical pharmacology suggests that Sermorelin is very unlikely to be associated with drug abuse or dependence and there have been no reports of this from clinical trials.
Read the entire FDA prescribing information for Sermorelin Acetate (Sermorelin)
© Sermorelin Acetate Patient Information is supplied by Cerner Multum, Inc. and Sermorelin Acetate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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