Seromycin Side Effects Center

Last updated on RxList: 8/1/2022
Seromycin Side Effects Center

What Is Seromycin?

Seromycin (cycloserine capsules) is a broad–spectrum antibiotic used to treat active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible to this drug and when treatment with the primary medications (streptomycin, isoniazid, rifampin, and ethambutol) has proved inadequate. Seromycin should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent. Seromycin may be effective in the treatment of acute urinary tract infections caused by susceptible strains of gram–positive and gram–negative bacteria, especially Enterobacter spp. and Escherichia coli.

What Are Side Effects of Seromycin?

Common side effects of Seromycin include:

  • drowsiness,
  • dizziness,
  • headache,
  • tremors (shaking),
  • spinning sensation (vertigo),
  • mood changes,
  • numbness and tingling,
  • speech problems,
  • skin rash, and
  • thoughts of suicide.

Seromycin may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • seizure,
  • confusion,
  • depressed mood,
  • unusual thoughts or behavior,
  • severe drowsiness,
  • severe dizziness,
  • spinning sensation,
  • swelling,
  • rapid weight gain,
  • overactive reflexes,
  • tremors,
  • shaking,
  • trouble speaking, and
  • muscle weakness

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Seromycin

The usual dosage of Seromycin is 500 mg to 1 g daily in divided doses monitored by blood levels. The initial adult dosage of Seromycin most frequently given is 250 mg twice daily at 12–hour intervals for the first 2 weeks.

What Drugs, Substances, or Supplements Interact with Seromycin?

Seromycin may interact with alcohol, ethionamide, and isoniazid. Tell your doctor all medications and supplements you use.

Seromycin During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Seromycin it is unknown how it would affect a fetus. Because of the potential for serious adverse reactions in nursing infants, breastfeeding while using Seromycin is not recommended.

Additional Information

Our Seromycin (cycloserine capsules) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow
Seromycin Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a seizure;
  • confusion, depressed mood, unusual thoughts or behavior;
  • severe drowsiness, severe dizziness or spinning sensation;
  • swelling, rapid weight gain;
  • overactive reflexes, tremors or shaking;
  • trouble speaking; or
  • muscle weakness.

Common side effects may include:

  • dizziness, drowsiness;
  • mood changes;
  • headache; or
  • numbness, tingling, burning pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Seromycin (Cycloserine Capsules )


Bowel regularity means a bowel movement every day. See Answer
Seromycin Professional Information


Most adverse reactions occurring during therapy with Seromycin involve the nervous system or are manifestations of drug hypersensitivity. The following side effects have been observed in patients receiving Seromycin:

Nervous system symptoms (which appear to be related to higher dosages of the drug, i.e., more than 500 mg daily)
Drowsiness and somnolence
Confusion and disorientation with loss of memory
Psychoses, possibly with suicidal tendencies
Character changes
Major and minor (localized) clonic seizures
  Sudden development of congestive heart failure in patients receiving 1 to 1.5 g of Seromycin daily has been reported
Allergy (apparently not related to dosage)
Skin rash  
  Elevated serum transaminase, especially in patients with preexisting liver disease

Read the entire FDA prescribing information for Seromycin (Cycloserine Capsules )

© Seromycin Patient Information is supplied by Cerner Multum, Inc. and Seromycin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors