Medical Editor: John P. Cunha, DO, FACOEP
Seromycin (cycloserine capsules) is a broad–spectrum antibiotic used to treat active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible to this drug and when treatment with the primary medications (streptomycin, isoniazid, rifampin, and ethambutol) has proved inadequate. Seromycin should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent. Seromycin may be effective in the treatment of acute urinary tract infections caused by susceptible strains of gram–positive and gram–negative bacteria, especially Enterobacter spp. and Escherichia coli. Common side effects of Seromycin include:
- tremors (shaking),
- spinning sensation (vertigo),
- mood changes,
- numbness and tingling,
- speech problems,
- skin rash, and
- thoughts of suicide.
The usual dosage of Seromycin is 500 mg to 1 g daily in divided doses monitored by blood levels. The initial adult dosage of Seromycin most frequently given is 250 mg twice daily at 12–hour intervals for the first 2 weeks. Seromycin may interact with alcohol, ethionamide, and isoniazid. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Seromycin it is unknown how it would affect a fetus. Because of the potential for serious adverse reactions in nursing infants, breastfeeding while using Seromycin is not recommended.
Our Seromycin (cycloserine capsules) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Most adverse reactions occurring during therapy with Seromycin involve the nervous system or are manifestations of drug hypersensitivity. The following side effects have been observed in patients receiving Seromycin:
|Nervous system symptoms (which appear to be related to higher dosages of the drug, i.e., more than 500 mg daily)|
Drowsiness and somnolence
Confusion and disorientation with loss of memory
Psychoses, possibly with suicidal tendencies
Major and minor (localized) clonic seizures
|Sudden development of congestive heart failure in patients receiving 1 to 1.5 g of Seromycin daily has been reported|
|Allergy (apparently not related to dosage)|
|Elevated serum transaminase, especially in patients with preexisting liver disease|
Read the entire FDA prescribing information for Seromycin (Cycloserine Capsules )