Seroquel vs. Depakote

Are Seroquel and Depakote the Same Thing?

Seroquel (quetiapine) and Depakote (divalproex sodium) are used to treat bipolar disorder.

Seroquel is also used to treat schizophrenia in adults and children who are at least 13 years old, and to treat major depression.

Depakote is also used to treat epilepsy and migraine headaches.

What Are Possible Side Effects of Seroquel?

Common side effects of Seroquel include:

Older adults with dementia may have a slightly increased risk of death when taking Seroquel.

What Are Possible Side Effects of Depakote?

Common side effects of Depakote include:

  • drowsiness,
  • weakness,
  • nausea,
  • vomiting,
  • stomach upset,
  • diarrhea,
  • constipation,
  • mood swings,
  • changes in menstrual periods,
  • enlarged breasts,
  • weight changes,
  • agitation,
  • tremor (shaking),
  • vision changes,
  • unusual or unpleasant taste in your mouth, and
  • hair loss.

What Is Seroquel?

Seroquel (quetiapine) is a psychotropic medication used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel is also used in the treatment of major depression and bipolar disorder.

What Is Depakote?

Depakote (divalproex sodium) is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches.

Antiepileptic drugs (AEDs), including Depakote, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Tell your doctor if you have new or worsening depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

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What Drugs Interact With Seroquel?

Seroquel may also interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), medications to treat Parkinson's disease, steroids, antibiotics, antifungal medications, anti-malaria medications, heart rhythm medicines, medications to treat HIV or AIDS, or migraine headache medicines.

What Drugs Interact With Depakote?

The recommended initial dose of Depakote to treat mania is 750 mg daily in divided doses. The dose of Depakote to treat epilepsy as monotherapy should be initiated at 10 to 15 mg/kg/day. The recommended starting dose of Depakote to treat migraines is 250 mg twice daily.

How Should Seroquel Be Taken?

Dosing preparations are 25, 50, 100, 200, 300, and 400 mg tablets.

How Should Depakote Be Taken?

Depakote (ziprasidone HCl) is available as capsules and Depakote (ziprasidone mesylate) is available as an injection for intramuscular use.

Depakote Capsules should be administered at an initial daily dose of 20 mg twice daily with food. For intramuscular dosing, the recommended dose of Depakote is 10 mg to 20 mg administered as required up to a maximum dose of 40 mg per day.

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Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

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If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

RxList. Seroquel Side Effects Drug Center
https://www.rxlist.com/seroquel-side-effects-drug-center.htm
RxList. Depakote Side Effects Drug Center.
https://www.rxlist.com/depakote-side-effects-drug-center.htm

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