Seroquel vs. Geodon

Are Seroquel and Geodon the Same Thing?

Seroquel (quetiapine) and Geodon (ziprasidone HCl and ziprasidone mesylate) are psychotropic medications (antipsychotics) used to treat schizophrenia and bipolar disorder.

Seroquel is also used to treat major depression.

What Are Possible Side Effects of Seroquel?

Common side effects of Seroquel include:

  • mood or behavior changes,
  • constipation,
  • stomach pain,
  • upset stomach,
  • nausea,
  • vomiting,
  • drowsiness,
  • dizziness,
  • lightheadedness,
  • tiredness,
  • headache,
  • trouble sleeping,
  • dry mouth,
  • sore throat,
  • breast swelling or discharge,
  • missed menstrual periods,
  • increased appetite, or
  • weight gain.

Older adults with dementia may have a slightly increased risk of death when taking Seroquel.

What Are Possible Side Effects of Geodon?

Common side effects of Geodon include:

  • feeling unusually tired or sleepy;
  • nausea,
  • vomiting,
  • upset stomach,
  • loss of appetite;
  • constipation;
  • dizziness,
  • drowsiness;
  • restlessness;
  • anxiety,
  • headache,
  • depression;
  • abnormal muscle movements,
  • such as tremor,
  • shuffling, and
  • uncontrolled involuntary movements,
  • muscle pain or twitching;
  • diarrhea;
  • skin rash;
  • weight gain, and
  • increased cough or runny or stuffy nose.

Serious side effects of Geodon include

This is not a complete list of side effects, and others may occur.

What is Seroquel?

Seroquel (quetiapine) is a psychotropic medication used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel is also used in the treatment of major depression and bipolar disorder.

What is Geodon?

Geodon (ziprasidone HCl and ziprasidone mesylate) is an atypical antipsychotic used to treat symptoms of schizophrenia and acute manic or mixed episodes associated with bipolar disorder. Geodon also can be used as maintenance treatment of bipolar disorder when added to lithium or valproate.

What Drugs Interact With Seroquel?

Seroquel may also interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), medications to treat Parkinson's disease, steroids, antibiotics, antifungal medications, anti-malaria medications, heart rhythm medicines, medications to treat HIV or AIDS, or migraine headache medicines.

What Drugs Interact With Geodon?

Geodon may interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), blood pressure medicines, and medications to treat Parkinson's disease.

Geodon may also interact with diuretics (water pills), heart rhythm medicines, blood pressure medicines, amazepine, cisapride, or haloperidol.

How Should Seroquel Be Taken?

Dosing preparations are 25, 50, 100, 200, 300, and 400 mg tablets.

How Should Geodon Be Taken?

Geodon (ziprasidone HCl) is available as capsules and Geodon (ziprasidone mesylate) is available as an injection for intramuscular use.

Geodon Capsules should be administered at an initial daily dose of 20 mg twice daily with food. For intramuscular dosing, the recommended dose of Geodon is 10 mg to 20 mg administered as required up to a maximum dose of 40 mg per day.


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If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the or websites for more information.

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RxList. Seroquel Side Effects Drug Center
RxList. Geodon Side Effects Drug Center.

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