How Do Serotonin 5HT-receptor Agonists Work?

Reviewed on 9/7/2021

HOW DO SEROTONIN 5-HT-RECEPTOR AGONISTS WORK?

Serotonin 5-HT-receptor agonists are drugs used for treating moderately severe to severe migraine headaches. 

Migraine occurs when a specific nerve in the blood vessels sends pain signals to the brain. As a result, inflammatory substances get released into the nerves and blood vessels of the head, causing dilation and inflammation of these blood vessels.

There are two types of antimigraine agents:

Abortive agents: These agents abort an established migraine attack. 

Preventive antimigraine agents: These agents are given prophylactically to reduce the number of migraine attacks.

Serotonin 5-HT-receptor agonists work as abortive agents. Abortive agents constrict the blood vessels and prevent inflammation by stimulating 5-HT-receptors in the brain. 5-HT-receptor agonists bind to the 5-HT-receptors in the brain and inhibit the release of serotonin to reduce pain, nausea, and other symptoms of migraine.

HOW ARE SEROTONIN 5-HT-RECEPTOR AGONISTS USED?

Serotonin 5-HT-receptor agonists are used for treating moderately severe to severe migraine headaches. They are also indicated for treating hypoactive sexual desire disorder.

WHAT ARE SIDE EFFECTS OF SEROTONIN 5-HT-RECEPTOR AGONISTS?

The most common side effects of serotonin 5-HT-receptor agonists include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow

WHAT ARE NAMES OF SEROTONIN 5-HT-RECEPTOR AGONISTS?

Generic and brand names of serotonin 5-HT-receptor agonists include:

References
https://reference.medscape.com/drugs/serotonin-5-ht-receptor-agonists

https://pubmed.ncbi.nlm.nih.gov/1646288/

https://pubmed.ncbi.nlm.nih.gov/11480266/

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