How Do Serotonin 5 HT1F Agonists Work?

Serotonin 5-HT1F agonists are abortive agents used for the treatment of acute migraine attacks.

Migraine occurs when a specific nerve in the blood vessels sends pain signals to the brain. As a result, inflammatory substances get released into the nerves and blood vessels of the head, causing dilation and inflammation of these blood vessels.

There are two types of antimigraine agents:

• Abortive agents: These agents abort an established migraine attack. 
• Preventive antimigraine agents: These agents are given prophylactically to reduce the number of migraine attacks.

Unlike other abortive agents used for migraine treatment, serotonin 5-HT1F does not cause constriction of blood vessels. Serotonin 5-HT1F binds to serotonin 5-HT1F receptors in the brain to block the release of glutamate. Glutamate is an excitatory neurotransmitter that causes increased brain activity. Studies have shown that increased brain activity in specific areas of the brain causes migraines. Thus, serotonin 5-HT1F receptor agonists alleviate migraines by reducing brain activity without interfering with normal cell function.

Serotonin 5-HT1F agonists are used for treating acute migraine attacks.

Some of the common side effects experienced with serotonin 5-HT1F agonists include:

• Dizziness
• Sedation
• Fatigue
• Nausea or vomiting
• Muscle weakness
• Vertigo
• Incoordination
• Lethargy
• Visual impairment
• Feeling abnormal
• Palpitations
• Anxiety
• Tremor
• Restlessness
• Sleep abnormalities
• Confusion
• Euphoric mood
• Muscle spasm
• Chest discomfort
• Shortness of breath
• Hallucinations
• Limb discomfort
• Feeling hot or cold

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

Generic and brand names of serotonin 5-HT1F agonists include:

• Lasmiditan
• Reyvow