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Silvadene

Last reviewed on RxList: 2/27/2019
Silvadene Side Effects Center

Last reviewed on RxList 2/27/2019

Silvadene Cream 1% (silver sulfadiazine) is a topical (for the skin) antibiotic used to treat or prevent infections on areas of burned skin. Silvadene Cream is available in generic form. Common side effects of Silvadene Cream include:

  • pain,
  • burning, or
  • itching of the treated skin,
  • upset stomach, or
  • discoloration (brown/gray/blue) of skin and mucous membranes (such as the gums).

Burn areas should be covered with Silvadene Cream 1% at all times. The cream should be applied once to twice daily to a thickness of approximately 1/16 inch. Whenever necessary, the cream should be reapplied to any areas where it has been removed by patient activity. Silvadene Cream may interact with cimetidine. Tell your doctor all medications you use. During pregnancy, Silvadene Cream should be used only when prescribed. It must not be used near the expected delivery date because of possible harm to the fetus. It is unknown if this medication passes into breast milk. Similar drugs pass into breast milk and may harm nursing infants who are ill, premature, less than 2 months old, or who have certain disorders (such as jaundice, high blood levels of bilirubin, G6PD deficiency). Breast-feeding while using this drug is not recommended in infants with these conditions. Consult your doctor before breast-feeding.

Our Silvadene Cream 1% (silver sulfadiazine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Silvadene Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when silver sulfadiazine is applied to the skin, side effects can occur if the medicine is absorbed into your bloodstream.

Call your doctor at once if you have:

  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • kidney problems--red or pink urine, little or no urinating, swelling, rapid weight gain;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Silvadene (Silver Sulfadiazine)

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Silvadene Professional Information

SIDE EFFECTS

Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy.1,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count. Maximal white blood cell depression occurs within 2 to 4 days of initiation of therapy. Rebound to normal leukocyte levels follows onset within 2 to 3 days. Recovery is not influenced by continuation of silver sulfadiazine therapy. An increased incidence of leukopenia has been reported in patients treated concurrently with cimetidine.

Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis.

Reduction in bacterial growth after application of topical antibacterial agents has been reported to permit spontaneous healing of deep partial-thickness burns by preventing conversion of the partial thickness to full thickness by sepsis. However, reduction in bacterial colonization has caused delayed separation, in some cases necessitating escharotomy in order to prevent contracture.

Read the entire FDA prescribing information for Silvadene (Silver Sulfadiazine)

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© Silvadene Patient Information is supplied by Cerner Multum, Inc. and Silvadene Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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