Simponi vs. Eticovo

Are Simponi and Eticovo the Same Thing?

Simponi (golimumab injection) and Eticovo (etanercept-ykro) are used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall).

Eticovo is also used to treat polyarticular juvenile idiopathic arthritis (JIA) in patients aged 2 years or older and plaque psoriasis in patients 4 years or older.

Simponi and Eticovo belong to different drug classes. Simponi is a human IgG1k monoclonal antibody and Eticovo is a tumor necrosis factor (TNF) blocker. Eticovo is biosimilar to Enbrel (etanercept).

Side effects of Simponi and Eticovo that are similar include injection site reactions (redness, itching, pain, or swelling).

Side effects of Simponi that are different from Eticovo include dizziness and cold symptoms (stuffy nose, sneezing, sore throat).

Side effects of Eticovo that are different from Simponi include infections (such as upper respiratory infections, nasopharyngitis, sinusitis, and influenza), diarrhea, rash, itching, fever, and hives.

Both Simponi and Eticovo may interact with abatacept and anakinra.

Simponi may also interact with other monoclonal antibodies, blood thinners, cyclosporine, digoxin, theophylline, seizure medications, or heart rhythm medications.

Eticovo may also interact with “live vaccines,” cyclophosphamide, and sulfasalazine.

What Are Possible Side Effects of Simponi?

Common side effects of Simponi include:

  • dizziness,
  • cold symptoms (stuffy nose, sneezing, sore throat), or
  • injection site reactions (redness, itching, pain, or swelling).

Tell your doctor if you have serious side effects of Simponi including:

What Are Possible Side Effects of Eticovo?

Common side effects of Eticovo include:

  • infections (such as upper respiratory infections, nasopharyngitis, sinusitis, and influenza),
  • injection site reactions,
  • diarrhea,
  • rash,
  • itching,
  • fever, and
  • hives

What Is Simponi?

Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall). Simponi works by blocking a protein (tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.

What Is Eticovo?

Eticovo (etanercept-ykro) is a tumor necrosis factor (TNF) blocker indicated for the treatment of rheumatoid arthritis (RA), polyarticular juvenile idiopathic arthritis (JIA) in patients aged 2 years or older, psoriatic arthritis (PsA), ankylosing spondylitis (AS), and plaque psoriasis (PsO) in patients 4 years or older. Eticovo is biosimilar to Enbrel (etanercept).

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What Drugs Interact With Simponi?

Simponi may interact with abatacept, anakinra, rituximab, blood thinners, cyclosporine, digoxin, theophylline, seizure medications, or heart rhythm medications. Tell your doctor all medications you use. During pregnancy, Simponi should be used only when prescribed. It is unknown if this drug passes into breast milk. Because of the potential risk to the infant, consult your doctor before breastfeeding.

What Drugs Interact With Eticovo?

Eticovo may interact with "live vaccines," anakinra, abatacept, and cyclophosphamide, and sulfasalazine. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Eticovo; it is unknown how it would affect a fetus. Eticovo passes into breast milk in low levels. Consult your doctor before breastfeeding.

How Should Simponi Be Taken?

The Simponi dose regimen is 50 mg administered by subcutaneous (SC) injection once a month.

How Should Eticovo Be Taken?

The dose of Eticovo to treat adult rheumatoid arthritis and psoriatic arthritis is 50 mg once weekly with or without methotrexate (MTX). The dose of Eticovo to treat ankylosing spondylitis is 50 mg once weekly. The dose of Eticovo to treat adult plaque psoriasis is 50 mg twice weekly for 3 months, followed by 50 mg once weekly. The dose of Eticovo to treat pediatric plaque psoriasis or plaque psoriasis (patients who weigh 63 kg or more) is 50 mg once weekly.

QUESTION

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References

Janssen Biotech, Inc. Simponi Product Information.
https://www.simponi.com/
Samsung Bioepis. Eticovo Product Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761066s000lbl.pdf

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