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Sinemet vs. Requip

Are Sinemet and Requip the Same Thing?

Sinemet (carbidopa-levodopa) and Requip (ropinirole) are used to treat Parkinson symptoms such as muscle stiffness, tremors, spasms, and poor muscle control.

Sinemet is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication.

Requip is also used to treat restless legs syndrome (RLS).

Sinemet and Requip belong to different drug classes. Sinemet is a combination of an inhibitor of aromatic amino acid decarboxylation and an aromatic amino acid and Requip is a non-ergoline dopamine agonist.

What Are Possible Side Effects of Sinemet?

Common side effects of Sinemet include:

Tell your doctor if you experience unlikely but serious side effects including:
  • greatly increased eye blinking/twitching,
  • fainting,
  • mental/mood changes (e.g., confusion, depression, hallucinations, thoughts of suicide),
  • unusual strong urges (such as increased gambling, increased sexual urges),
  • or worsening of involuntary movements/spasms.

What Are Possible Side Effects of Requip?

Common side effects of Requip include:

QUESTION

Parkinson's disease is only seen in people of advanced age. See Answer

What is Sinemet?

Sinemet (carbidopa-levodopa) is a combination of an inhibitor of aromatic amino acid decarboxylation and an aromatic amino acid used to treat Parkinson symptoms such as

  • muscle stiffness,
  • tremors,
  • spasms,
  • and poor muscle control.
Sinemet is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication.

What is Requip?

Requip (ropinirole) is a non-ergoline dopamine agonist used to treat symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. Requip is also used to treat restless legs syndrome (RLS). Requip is available in generic form.

What Drugs Interact With Sinemet?

Sinemet may interact with metoclopramide, isoniazid, phenytoin, papaverine, antidepressants, or blood pressure medications.

Sinemet may also interact with other Parkinson's medications or medicines to treat psychiatric disorders.

What Drugs Interact With Requip?

Requip may interact with other Parkinson's medications, metoclopramide, or medicines to treat psychiatric disorders.

Requip may also interact with ciprofloxacin, fluvoxamine, omeprazole, medication used to treat nausea and vomiting, or estrogen.

Do not stop taking Requip suddenly or change your doses, or you could have unpleasant withdrawal symptoms such as fever, muscle stiffness, and confusion.

SLIDESHOW

Dementia, Alzheimer's Disease, and Aging Brains See Slideshow

How Should Sinemet Be Taken?

Starting dosage is one tablet of Sinemet 25-100 (carbidopa-levodopa) three times a day. Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets a day is reached.

How Should Requip Be Taken?

The dose of Requip depends on the condition being treated and the patient's response.

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References
Medical Editor: John P. Cunha, DO, FACOEP
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