Single gene disease: Any genetic disorder caused by a change affecting only one gene.
There are thousands of single-gene diseases including achondroplasia,
cystic fibrosis, hemophilia, Huntington disease, muscular dystrophy, and
sickle cell disease .
Single-gene diseases usually follow simple Mendelian patterns of inheritance -- autosomal dominant, an autosomal
recessive, or an X-linked.
Single gene diseases are as opposed to polygenic diseases which are caused by a combination of two or more genes.