Skelaxin vs. Baclofen (Gablofen, Lioresal)

Are Skelaxin and Baclofen the Same Thing?

Skelaxin (metaxalone) and baclofen are skeletal muscle relaxants prescribed for treatment of painful muscle spasms.

A difference is that baclofen is also used for treating muscle clonus, rigidity, and pain caused by multiple sclerosis. Baclofen is also injected into the spinal cord to treat severe spasticity, spinal cord injuries, and other spinal cord diseases.

Brand names for baclofen include Gablofen and Lioresal.

What Are Possible Side Effects of Skelaxin?

Common side effects of Skelaxin include:

Tell your doctor if you experience serious side effects of Skelaxin including stomach pain, loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What Are Possible Side Effects of Baclofen?

Common side effects of Baclofen include:

  • sleepiness
  • drowsiness
  • dizziness
  • nausea
  • vomiting
  • low blood pressure
  • headache
  • convulsions
  • seizures
  • low muscle tone
  • weakness
  • agitation
  • constipation
  • chills
  • urinary retention or urinary frequency
  • confusion, and
  • trouble sleeping

What is Skelaxin?

Skelaxin (metaxalone) is a skeletal muscle relaxant prescribed for the short-term treatment of painful muscle spasms. Skelaxin is available as a generic drug.

What is Baclofen?

Gablofen (baclofen) is a skeletal muscle relaxant used to treat severe spasticity, a very intense tightness of muscles that may cause pain and uncontrollable spasms of the arms, legs, hands, and feet. Gablofen is also used to manage severe spasticity of cerebral or spinal origin in adult and pediatric patients age 4 years and older.


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What Drugs Interact With Skelaxin?

Significant drug interactions have not been reported with Skelaxin although it may increase the sedative effects of alcohol and drugs that cause sedation.

What Drugs Interact With Baclofen?

There are no data to indicate significant interactions with Baclofen and other drugs, however Baclofen may interact with morphine.

How Should Skelaxin Be Taken?

Skelaxin's usual dose is 800 mg taken three or four times daily.

How Should Baclofen Be Taken?

Baclofen is administered by the intrathecal route, meaning it is administered via spinal catheter or lumbar puncture.


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RxList. Skelaxin Side Effects Drug Center.
RxList. Gablofen Side Effects Drug Center.

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