Skelaxin vs. Flexeril

Are Skelaxin and Flexeril the Same Thing?

Skelaxin (metaxalone) and Flexeril (cyclobenzaprine) are skeletal muscle relaxants prescribed to treat painful muscle spasms.

Side effects of Skelaxin and Flexeril that are similar include drowsiness, dizziness, headache, nausea, or stomach upset or pain.

What Are Possible Side Effects of Skelaxin?

Common side effects of Skelaxin include:

  • drowsiness,
  • dizziness,
  • headache,
  • nervousness,
  • irritability,
  • nausea,
  • vomiting,
  • upset stomach, or
  • skin rash.

Tell your doctor if you experience serious side effects of Skelaxin including stomach pain, loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

What Are Possible Side Effects of Flexeril?

Common side effects of Flexeril include:

  • sleepiness
  • drowsiness
  • dizziness
  • nausea
  • vomiting
  • low blood pressure
  • headache
  • convulsions
  • seizures
  • low muscle tone
  • weakness
  • agitation
  • constipation
  • chills
  • urinary retention or urinary frequency
  • confusion, and
  • trouble sleeping

What Is Skelaxin?

Skelaxin (metaxalone) is a skeletal muscle relaxant prescribed for the short-term treatment of painful muscle spasms. Skelaxin is available as a generic drug.

What Is Flexeril?

Flexeril (cyclobenzaprine) is a muscle relaxant indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

SLIDESHOW

Back Pain: 16 Back Pain Truths and Myths See Slideshow

What Drugs Interact With Skelaxin?

Significant drug interactions have not been reported with Skelaxin although it may increase the sedative effects of alcohol and drugs that cause sedation.

What Drugs Interact With Flexeril?

Flexeril especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.

How Should Skelaxin Be Taken?

Skelaxin's usual dose is 800 mg taken three or four times daily.

How Should Flexeril Be Taken?

For most patients, the recommended dose of Flexeril is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of Flexeril for periods longer than two or three weeks is not recommended.

QUESTION

Medically speaking, the term "myalgia" refers to what type of pain? See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

FDA. Skelaxin Medication Guide.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/013217s053lbl.pdf
FDA. Flexeril Product Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017821s051lbl.pdf

Health Solutions From Our Sponsors