Skyrizi vs. Humira

Are Skyrizi and Humira the Same Thing?

Skyrizi (risankizumab-rzaa) and Humira (etanercept) are used to treat plaque psoriasis.

Humira is also used to treat rheumatoid arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis.

Skyrizi and Humira belong to different drug classes. Skyrizi is an interleukin-23 antagonist and Humira is a tumor necrosis factor (TNF) inhibitor.

Side effects of Skyrizi and Humira that are similar include headache and injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth).

Side effects of Skyrizi that are different from Humira include upper respiratory infections, fatigue, and tinea infections (such as ringworm, athlete's foot, and jock itch).

Side effects of Humira that are different from Skyrizi include mild nausea, vomiting, diarrhea, stomach pain, heartburn, weight changes, cold symptoms (cough, runny nose), and weakness.

Both Skyrizi and Humira may interact with “live” vaccines.

Humira may also interact with anakinra, cyclophosphamide, sulfasalazine, abatacept, insulin or oral diabetes medicines, and drugs that weaken your immune system (such as cancer medicines or steroids).

What Are Possible Side Effects of Skyrizi?

Side effects of Skyrizi include:

  • upper respiratory infections,
  • headache,
  • fatigue,
  • injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth), and
  • tinea infections (such as ringworm, athlete's foot and jock itch)

What Are Possible Side Effects of Humira?

Common side effects of Humira include:

  • injection site reactions (redness, itching, pain, bruising, swelling, or bleeding),
  • headache,
  • suffy nose,
  • sinus pain, or
  • stomach pain.

Tell your doctor if you have serious side effects of Humira including:

  • fast/irregular/pounding heartbeat,
  • stomach pain,
  • blood in the stools,
  • mental/mood changes,
  • severe headache,
  • easy bruising or bleeding,
  • dark urine,
  • yellowing eyes and skin,
  • leg pain or swelling,
  • numbness or tingling of the arms/hands/legs/feet,
  • unsteadiness,
  • unexplained muscle weakness,
  • difficulty with speaking/chewing/swallowing/facial movements,
  • vision changes,
  • extreme fatigue,
  • joint pain, or
  • butterfly-shaped rash on the nose and cheeks.

What Is Skyrizi?

Skyrizi (risankizumab-rzaa) is an interleukin-23 antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

What Is Humira?

Humira (adalimumab) is an injectable protein (antibody) used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. Humira is also used to treat Crohn's disease after other drugs have been tried without successful treatment of symptoms.

What Drugs Interact With Skyrizi?

Skyrizi may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Skyrizi; it is unknown how it would affect a fetus. It is unknown if Skyrizi passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Humira?

Humira may interact with azathioprine or mercaptopurine. Asacol may also interact with pentamidine, tacrolimus, amphotericin B, antibiotics, antiviral medicines, cancer medicine, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs).

Humira may also interact with abatacept, anakinra, infliximab, etanercept, certolizumab pegol, golimumab, or rituximab.

How Should Skyrizi Be Taken?

The dose of Skyrizi is 150 mg (two 75 mg injections) administered by subcutaneous injection at Week 0, Week 4 and every 12 weeks thereafter.

How Should Humira Be Taken?

Humira is given by an injection under the skin. Your doctor will tell you how often to take an injection of Humira. This is based on your condition to be treated. Do not inject Humira more often than you were prescribed.

Do not try to inject Humira yourself until you have been shown the right way to give the injections. If your doctor decides that you or a caregiver may be able to give your injections of Humira at home, you should receive training on the right way to prepare and inject Humira.

Do not miss any doses of Humira unless your doctor says it is okay. If you forget to take Humira, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time. This will put you back on schedule.

In case you are not sure when to inject Humira, call your doctor or pharmacist.

If you take more Humira than you were told to take, call your doctor.


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AbbVie Inc. Skyrizi Product Information.
Abbvie. Humira Product Monograph.

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