Skyrizi vs. Simponi

Are Skyrizi and Simponi the Same Thing?

Skyrizi (risankizumab-rzaa) and Simponi (golimumab injection) are used to treat different types of psoriasis.

Skyrizi is used to treat moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Simponi is used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and ulcerative colitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall).

Skyrizi and Simponi belong to different drug classes. Skyrizi is an interleukin-23 antagonist and Simponi is a tumor necrosis factor (TNF) inhibitor.

Side effects of Skyrizi and Simponi that are similar include injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth).

Side effects of Skyrizi that are different from Simponi include upper respiratory infections, headache, fatigue, and tinea infections (such as ringworm, athlete's foot, and jock itch).

Side effects of Simponi that are different from Skyrizi include dizziness and cold symptoms (stuffy nose, sneezing, sore throat).

Both Skyrizi and Simponi may interact with "live" vaccines.

Simponi may also interact with abatacept, anakinra, rituximab, blood thinners, cyclosporine, digoxin, theophylline, seizure medications, or heart rhythm medications.

What Are Possible Side Effects of Skyrizi?

Side effects of Skyrizi include:

  • upper respiratory infections,
  • headache,
  • fatigue,
  • injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth), and
  • tinea infections (such as ringworm, athlete's foot and jock itch)

What Are Possible Side Effects of Simponi?

Common side effects of Simponi include:

  • dizziness,
  • cold symptoms (stuffy nose, sneezing, sore throat), or
  • injection site reactions (redness, itching, pain, or swelling).

Tell your doctor if you have serious side effects of Simponi including:

QUESTION

Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer

What Is Skyrizi?

Skyrizi (risankizumab-rzaa) is an interleukin-23 antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

What Is Simponi?

Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall). Simponi works by blocking a protein (tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.

What Drugs Interact With Skyrizi?

Skyrizi may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Skyrizi; it is unknown how it would affect a fetus. It is unknown if Skyrizi passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Simponi?

Simponi may interact with abatacept, anakinra, rituximab, blood thinners, cyclosporine, digoxin, theophylline, seizure medications, or heart rhythm medications. Tell your doctor all medications you use.

SLIDESHOW

Types of Psoriasis: Medical Pictures and Treatments See Slideshow

How Should Skyrizi Be Taken?

The dose of Skyrizi is 150 mg (two 75 mg injections) administered by subcutaneous injection at Week 0, Week 4 and every 12 weeks thereafter.

How Should Simponi Be Taken?

The Simponi dose regimen is 50 mg administered by subcutaneous (SC) injection once a month.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
SOURCE:

AbbVie Inc. Skyrizi Product Information.
https://www.skyrizi.com
Janssen Biotech, Inc. Simponi Product Monograph.
https://www.simponi.com/

Health Solutions From Our Sponsors