Slynd Side Effects Center

Last updated on RxList: 7/5/2022
Slynd Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Slynd?

Slynd (drospirenone) is a progestin indicated for use by females of reproductive potential to prevent pregnancy.

What Are Side Effects of Slynd?

Common side effects of Slynd include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Slynd

The dose of Slynd is one tablet taken daily for 28 days; one white active tablet daily during the first 24 days and one green inactive tablet daily during the 4 following days.

What Drugs, Substances, or Supplements Interact with Slynd?

Slynd may interact with efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant, and products containing St. John's wort, ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and nonsteroidal anti-inflammatory drugs (NSAIDs). Tell your doctor all medications and supplements you use.

Slynd During Pregnancy and Breastfeeding

Slynd is not intended for use during pregnancy. Discontinue Slynd if pregnancy occurs. Negligible amounts of Slynd pass into breast milk but it is not expected to affect breastfed infants. Consult your doctor before breastfeeding.

Additional Information

Our Slynd (drospirenone) Tablets, for Oral Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Slynd Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor or seek emergency medical help if you have severe pain in your lower stomach or side. This could be a sign of a tubal pregnancy (a pregnancy that implants in the fallopian tube instead of the uterus). A tubal pregnancy is a medical emergency.

Call your doctor at once if you have:

  • severe or ongoing nausea, vomiting, or diarrhea;
  • high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • liver problems--loss of appetite, upper stomach pain, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • symptoms of depression--sleep problems, weakness, tired feeling, mood changes.

Common side effects may include:

  • vaginal bleeding, menstrual cramps;
  • breast pain or tenderness;
  • headache;
  • nausea;
  • acne;
  • weight gain; or
  • decreased sex drive.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Slynd Professional Information


The following clinically significant adverse reactions are described elsewhere in other sections of the labeling:

  • Hyperkalemia [see WARNINGS AND PRECAUTIONS]
  • Bleeding Irregularities and Amenorrhea [see WARNINGS AND PRECAUTIONS]

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

The data described below reflect the exposure of SLYND in females of reproductive potential desiring to prevent pregnancy based on four clinical studies including Study CF111/303 [see Clinical Studies]. The mean time of SLYND exposure ranged from 197 to 328 days. The demographic profile for the pooled study data was: mean age 28 years; mean BMI 25 kg/m²; racial distribution was 83% White; 14% Black; 1% Asian and 2% Other.

Table 3 : Adverse Reactions Occurring in ≥ 1% of Females Receiving SLYND in Four Pooled Studies

Adverse Reaction Total
N = 2598
n (%)
Any adverse reaction 627 (24.1)
Acne 98 (3.8)
Metrorrhagia 72 (2.8)
Headache 71 (2.7)
Breast pain 57 (2.2)
Weight increased 50 (1.9)
Dysmenorrhea 49 (1.9)
Nausea 47 (1.8)
Vaginal hemorrhage 45 (1.7)
Libido decreased 33 (1.3)
Breast tenderness 31 (1.2)
Menstruation irregular 30 (1.2)

Read the entire FDA prescribing information for Slynd (Drospirenone Tablets)

© Slynd Patient Information is supplied by Cerner Multum, Inc. and Slynd Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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