Sodium Citrate, Citric Acid

Reviewed on 9/20/2021

What Is Sodium Citrate/Citric Acid and How Does It Work?

Sodium citrate/citric acid is used for urine alkalinization and for prevention of nephrolithiasis.

  • Sodium citrate/citric acid is available under the following different brand names: Albrights Solution, Bicitra, Cytra 2, Oracit, and Shohls Solution.

What Are Dosages of Sodium Citrate/Citric Acid?

Dosages of Sodium Citrate/Citric Acid:

Dosage Forms and Strengths

  • Sodium citrate/citric acid (1 mEq sodium equivalent to 1 mEq bicarbonate)

Oral Solution

  • (500mg/334mg)/5mL
  • (490mg/640mg)/5mL

Dosage Considerations – Should be Given as Follows:

Urine Alkalinization, Prevention of Nephrolithiasis

  • Adults: 10-30 mL diluted in up to 6 oz water/juice orally after meals and at bedtime as needed
  • Children 2 years and older: 5-15 mL diluted in 30-90 mL of water/juice orally after meals and at bedtime as needed
  • Children under 2 years: Based on physician's discretion
  • Follow with additional water if desired


Kidney Stones: Symptoms, Causes, and Treatment See Slideshow

What Are Side Effects Associated with Using Sodium Citrate/Citric Acid?

Side effects of sodium citrate/citric acid include:

  • Diarrhea
  • Nausea
  • Muscle spasms
  • Metabolic alkalosis
  • Vomiting
  • Stomach pain
  • Fluid retention

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Sodium Citrate/Citric Acid?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

What Are Warnings and Precautions for Sodium Citrate/Citric Acid?


  • This medication contains sodium citrate/citric acid. Do not take Albright's Solution, Bicitra, Cytra 2, Oracit, or Shohls Solution if you are allergic to sodium citrate/citric acid or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.


  • Hypersensitivity to drug or component of the formulation
  • Severe renal impairment
  • Sodium-restricted diet

Effects of Drug Abuse

  • No information available

Short-Term Effects

  • See "What Are Side Effects Associated with Using Sodium Citrate/Citric Acid?”

Long-Term Effects

  • See "What Are Side Effects Associated with Using Sodium Citrate/Citric Acid?”


  • Use with caution in high blood pressure, kidney or liver disease, cardiac failure, toxemia of pregnancy, peripheral/pulmonary edema, shock, or the severely ill
  • Do not dilute in tomato juice

Pregnancy and Lactation

  • Use sodium citrate/citric acid with caution during pregnancy if the benefits outweigh the risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
  • There is no information available regarding the use of sodium citrate/citric acid in lactating women. Consult a physician before breastfeeding.

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