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Solodyn

Last reviewed on RxList: 8/21/2018
Solodyn Side Effects Center

Last reviewed on RxList 8/21/2018

Solodyn (minocycline hydrochloride) is a tetracycline antibiotic used to treat many different bacterial infections, such as urinary tract infections, severe acne, gonorrhea, tick fever, chlamydia, and others. Solodyn is available in generic form. Common side effects of Solodyn include:

Tell your doctor if you have unlikely but serious side effects of Solodyn including:

  • sunburn (sun sensitivity),
  • muscle pain,
  • difficult or painful swallowing,
  • changes in the amount of urine,
  • pink urine, brown or gray tooth discoloration,
  • blue/gray/brown discoloration of the skin/lips/tongue/gums,
  • numbness and tingling of the hands and feet,
  • unusual tiredness,
  • stopping of menstrual periods, or
  • new signs of infection (e.g., fever, chills, persistent sore throat).

The recommended dosage of Solodyn is approximately 1 mg/kg once daily for 12 weeks. Solodyn may interact with cholesterol-lowering medications, isotretinoin, tretinoin, antacids, products containing bismuth subsalicylate (e.g. Pepto-Bismol), minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements, blood thinners, or penicillin antibiotics. Tell your doctor all medications or supplements you are taking. Solodyn is not recommended for use during pregnancy because of possible harm to a fetus. It should not be used in women or men trying to have a child. Women of child-bearing age and men should use birth control while taking this medication. This medication passes into breast milk in very small amounts. While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.

Our Solodyn (minocycline hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Solodyn Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This may be more likely with long-term use of minocycline, and the reaction may occur several weeks after you began using this medicine.

Call your doctor at once if you have:

  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
  • signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, loss of appetite, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes);
  • lupus-like syndrome (with long-term use of minocycline to treat acne)--joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color;
  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes; or
  • signs of inflammation in your body--swollen glands, flu symptoms, easy bruising or bleeding, severe tingling or numbness, muscle weakness, chest pain, new or worsening cough with fever, trouble breathing.

Common side effects may include:

  • nausea, diarrhea, loss of appetite;
  • dizziness, spinning sensation;
  • headache, feeling tired;
  • swollen tongue, cough, trouble swallowing;
  • muscle or joint pain;
  • rash, itching; or
  • discoloration of you skin or nails.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Solodyn (Minocycline Hydrochloride)

Solodyn Professional Information

SIDE EFFECTS

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice.

The following table summarizes selected adverse reactions reported in clinical trials at a rate of ≥ 1% for SOLODYN.

Table 2: Selected Treatment-Emergent Adverse Reactions in at least 1% of Clinical Trial Subjects

Adverse Reactions SOLODYN (1 mg/kg)
N = 674 (%)
PLACEBO
N = 364 (%)
At least one treatment emergent event 379 (56) 197 (54)
Headache 152 (23) 83 (23)
Fatigue 62 (9) 24 (7)
Dizziness 59 (9) 17 (5)
Pruritus 31 (5) 16 (4)
Malaise 26 (4) 9 (3)
Mood alteration 17 (3) 9 (3)
Somnolence 13 (2) 3 (1)
Urticaria 10 (2) 1 (0)
Tinnitus 10 (2) 5 (1)
Arthralgia 9 (1) 2 (0)
Vertigo 8 (1) 3 (1)
Dry mouth 7 (1) 5 (1)
Myalgia 7 (1) 4 (1)

Postmarketing Experience

Adverse reactions that have been reported with minocycline hydrochloride use in a variety of indications include:

Skin and hypersensitivity reactions: fixed drug eruptions, balanitis, erythema multiforme, Stevens-Johnson syndrome, anaphylactoid purpura, photosensitivity, pigmentation of skin and mucous membranes, hypersensitivity reactions, angioneurotic edema, anaphylaxis, DRESS syndrome [see WARNINGS AND PRECAUTIONS].

Autoimmune conditions: polyarthralgia, pericarditis, exacerbation of systemic lupus, pulmonary infiltrates with eosinophilia, transient lupus-like syndrome.

Central nervous system: pseudotumor cerebri, bulging fontanels in infants, decreased hearing.

Endocrine: brown-black microscopic thyroid discoloration, abnormal thyroid function. Oncology: thyroid cancer.

Oral: glossitis, dysphagia, tooth discoloration.

Gastrointestinal: enterocolitis, pancreatitis, hepatitis, liver failure.

Renal: reversible acute renal failure.

Hematology: hemolytic anemia, thrombocytopenia, eosinophilia.

Preliminary studies suggest that use of minocycline may have deleterious effects on human spermatogenesis [see Nonclinical Toxicology].

Read the entire FDA prescribing information for Solodyn (Minocycline Hydrochloride)

Related Resources for Solodyn

Related Health

Read the Solodyn User Reviews »

© Solodyn Patient Information is supplied by Cerner Multum, Inc. and Solodyn Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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