Solu Cortef

Last updated on RxList: 6/7/2021
Solu Cortef Side Effects Center

What Is Solu-Cortef?

Solu-Cortef (hydrocortisone sodium succinate) is a corticosteroid hormone (glucocorticoid) used to treat various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. Some strengths of Solu-Cortef are available in generic form.

What Are Side Effects of Solu-Cortef?

Common side effects of Solu-Cortef include:

  • stomach upset,
  • headache,
  • dizziness,
  • menstrual period changes,
  • trouble sleeping,
  • increased appetite,
  • weight gain, or
  • injection site reactions (pain, redness, or swelling).

Tell your doctor if you have any serious side effects of Solu-Cortef including:

Dosage for Solu-Cortef

The initial dose of Solu-Cortef is 100 mg to 500 mg, depending on the specific disease being treated. This dose may be repeated at intervals of 2, 4 or 6 hours depending on patient response and condition.

What Drugs, Substances, or Supplements Interact with Solu-Cortef?

Solu-Cortef may interact with aspirin and salicylates, birth control, blood thinners, bupropion, drugs for diabetes, drugs that cause potassium loss, estrogens, mifepristone, natalizumab, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, azole antifungals, rifamycins, anti-seizure medications, or herbal products. Tell your doctor all medications you are taking.

Solu-Cortef During Pregnancy or Breastfeeding

Solu-Cortef should be used only when prescribed during pregnancy. Infants born to mothers using this medication may have low levels of corticosteroid hormone. Tell your doctor if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn. This medication passes into breast milk. Although there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.

Solu-Cortef During Pregnancy or Breastfeeding

Additional Information

Our Solu-Cortef (hydrocortisone sodium succinate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Solu Cortef Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • muscle weakness, loss of muscle mass;
  • new or unusual pain in your joints, bones, or muscles;
  • severe headaches, ringing in your ears, pain behind your eyes;
  • unusual changes in mood or behavior;
  • a seizure;
  • hollowing or other skin changes where the injection was given;
  • numbness or tingling;
  • fluid retention--shortness of breath (even while lying down), swelling, rapid weight gain (especially in your face and midsection);
  • new signs of infection--such as fever, chills, cough, trouble breathing, sores in your mouth or on your skin, diarrhea, or burning when you urinate;
  • increased adrenal gland hormones--slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, menstrual changes, sexual changes; or
  • decreased adrenal gland hormones--weakness, tiredness, diarrhea, nausea, menstrual changes, skin discoloration, craving salty foods, and feeling light-headed.

Hydrocortisone can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • acne, dry skin;
  • increased sweating;
  • nausea, bloating;
  • increased appetite, weight gain; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Solu Cortef (Hydrocortisone Sodium Succinate)

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow
Solu Cortef Professional Information

SIDE EFFECTS

The following adverse reactions have been reported with SOLU-CORTEF or other corticosteroids:

Allergic reactions: Allergic or hypersensitivity reactions, anaphylactoid reaction, anaphylaxis, angioedema.

Blood and lymphatic system disorders: Leukocytosis.

Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS), pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.

Dermatologic: Acne, allergic dermatitis, burning or tingling (especially in the perineal area, after intravenous injection), cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.

Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.

Fluid and electrolyte disturbances: Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention.

Gastrointestinal: Abdominal distention, bowel/bladder dysfunction (after intrathecal administration), elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.

Metabolic: Negative nitrogen balance due to protein catabolism.

Musculoskeletal: Aseptic necrosis of femoral and humeral heads, Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, postinjection flare (following intra-articular use), steroid myopathy, tendon rupture, vertebral compression fractures.

Neurologic/Psychiatric: Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo. Arachnoiditis, meningitis, paraparesis/paraplegia, and sensory disturbances have occurred after intrathecal administration (see WARNINGS: Neurologic), epidural lipomatosis.

Ophthalmic: Central serous chorioretinopathy, exophthalmoses, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, rare instances of blindness associated with periocular injections.

Other: Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, injection site infections following non-sterile administration (see WARNINGS), malaise, moon face, weight gain.

Read the entire FDA prescribing information for Solu Cortef (Hydrocortisone Sodium Succinate)

© Solu Cortef Patient Information is supplied by Cerner Multum, Inc. and Solu Cortef Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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