Solu-Medrol vs. Prednisone

Are Solu-Medrol and Prednisone the Same Thing?

Solu-Medrol (methylprednisolone) and prednisone are corticosteroids used for severe or incapacitating allergic conditions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, rheumatic disorders, and several other conditions.

How Should Prednisone Be Taken?

The initial dosage of prednisone may vary from 5 mg to 60 mg per day, depending on the specific disease entity being treated.

What Are Possible Side Effects of Solu-Medrol?

Common side effects of Solu-Medrol include:

  • fluid retention,
  • weight gain,
  • high blood pressure,
  • potassium loss,
  • headache,
  • muscle weakness,
  • puffiness of the face,
  • hair growth on the face,
  • thinning and easy bruising of the skin,
  • glaucoma,
  • cataracts,
  • peptic ulcers,
  • high blood sugar (hyperglycemia),
  • irregular menstrual periods,
  • growth retardation in children,
  • convulsions,
  • nausea,
  • vomiting,
  • heartburn,
  • dizziness,
  • trouble sleeping,
  • appetite changes,
  • increased sweating,
  • acne,
  • psychiatric disturbances, and
  • injection site reactions (pain, redness, or swelling).

What Are Possible Side Effects of Prednisone?

Common side effects of Prednisone include:

  • headache,
  • nausea,
  • vomiting,
  • acne, thinning skin,
  • weight gain,
  • restlessness, and
  • trouble sleeping.

Tell your doctor if you experience serious side effects of prednisone including

QUESTION

Allergies can best be described as: See Answer

What Is Solu-Medrol?

Solu-Medrol (methylprednisolone) is a synthetic corticosteroid used for severe or incapacitating allergic conditions, dermatologic diseases, endocrine disorders, gastrointestinal diseases, rheumatic disorders, and several other conditions.

What Is Prednisone?

Prednisolone is an adrenocortical steroid used for multiple conditions including endocrine disorders, rheumatic disorders, collagen diseases, skin diseases, allergies, eye diseases, respiratory diseases, blood disorders, cancers, edematous states, gastrointestinal diseases, and nervous system disorders, among others. The brand name of this medication is discontinued, but generic versions may be available.

What Drugs Interact With Solu-Medrol?

Corticosteroids suppress the immune system and predispose patients to bacterial, fungal, or viral infections. Solu-medrol interacts with live vaccines, amphotericin B, erythromycin, warfarin, antidiabetic agents, estrogens, ketoconazole, and rifampin. It has not been adequately evaluated in pregnant or nursing women. Abruptly stopping Solu-medrol can cause symptoms of corticosteroid insufficiency.

What Drugs Interact With Prednisone?

Prednisone may interact with diuretics (water pills), blood thinners, cyclosporine, insulin or oral diabetes medications, rifampin, azole antifungals, or seizure medications.

Prednisone may also interact with antibiotics, anticholinesterase, isoniazid, bupropion, cholestyramine, cyclosporine, digitalis glycosides, estrogens (including oral contraceptives), barbiturates, ritonavir, indinavir, nonsteroidal anti-inflammatory drugs (NSAIDs), quetiapine, skin tests, thalidomide, and live or inactivated vaccines.

Following prolonged therapy, withdrawal of corticosteroids such as dexamethasone or prednisone may result in symptoms of the corticosteroid withdrawal syndrome including muscle or joint pain and feeling unwell (malaise).

How Should Solu-Medrol Be Taken?

Dosing depends on the condition being treated.

How Should Prednisone Be Taken?

The initial dosage of prednisone may vary from 5 mg to 60 mg per day, depending on the specific disease entity being treated.

SLIDESHOW

Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
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References
FDA. Solu-Medrol Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/011856s103s104lbl.pdf

FDA. Prednisone Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202020s000lbl.pdf

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