Spectazole Side Effects Center

Last updated on RxList: 6/17/2021
Spectazole Side Effects Center

What Is Spectazole?

Spectazole (econazole nitrate) Cream is a topical (for the skin) antifungal medication used to treat skin infections such as athlete's foot, jock itch, ringworm, tinea versicolor (a fungus that discolors the skin), and yeast infections. The brand name Spectazole is no longer available in the U.S. Generic versions may be available. Serious side effects of Spectazole (econazole nitrate) Cream use are unexpected.

What Are Side Effects of Spectazole?

Common side effects of Spectazole (econazole nitrate) Cream include:

  • burning,
  • stinging,
  • swelling,
  • irritation,
  • redness,
  • pimple-like bumps,
  • tenderness, or
  • flaking of the treated skin.

Tell your doctor if you have:

  • unusual or severe blistering,
  • itching,
  • redness,
  • peeling,
  • dryness,
  • swelling,
  • oozing, or
  • irritation of the skin, or
  • open sores after using Spectazole (econazole nitrate) Cream.

Dosage for Spectazole

Apply a sufficient dose of econazole nitrate cream to cover affected areas once daily in patients with tinea pedis, tinea cruris, tinea corporis, and tinea versicolor, and twice daily (morning and evening) in patients with cutaneous candidiasis.

What Drugs, Substances, or Supplements Interact with Spectazole?

Avoid using other topicals at the same time as econazole nitrate unless your doctor approves. Other skin medications may affect the absorption or effectiveness of econazole topical.

Spectazole During Pregnancy and Breastfeeding

Econazole nitrate should be used only if prescribed during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Spectazole (econazole nitrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Ringworm is caused by a fungus. See Answer
Spectazole Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe burning, redness, or stinging after applying the medicine.

Common side effects may include:

  • burning, itching, stinging, and redness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Spectazole (Econazole Nitrate)


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Spectazole Professional Information


During clinical trials, approximately 3% of patients treated with econazole nitrate 1% cream reported side effects thought possibly to be due to the drug, consisting mainly of burning, itching, stinging, and erythema. One case of pruritic rash has also been reported.

Read the entire FDA prescribing information for Spectazole (Econazole Nitrate)

© Spectazole Patient Information is supplied by Cerner Multum, Inc. and Spectazole Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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