Staphylococcal scalded skin syndrome: An infection of the skin with group II Staphylococcus aureus bacteria. The bacteria release toxins, causing inflamed, scaling skin that looks as though it has been burned. It is more common in children than in adults, but is more likely to cause death when it does occur in adults. Rehydration and intravenous antibiotics are the most common treatments. Steroids will worsen the condition, and should not be used. Abbreviated SSSS.