Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 4/26/2022
Stimate Side Effects Center

What Is Stimate?

Stimate (desmopressin acetate) nasal is a man-made form of a hormone that occurs naturally in the pituitary gland used to treat central cranial diabetes insipidus and increased thirst and urination caused by head surgery or head trauma. Stimate is also used to treat hemophilia A or von Willebrand's disease Type I.

What Are Side Effects of Stimate?

Common side effects of Stimate include:

  • headache
  • runny or stuffy nose
  • nausea
  • vomiting
  • stomach pain
  • upset stomach
  • flushing (warmth redness or tingly feeling) of the face
  • sore throat
  • cough or other cold symptoms
  • eye redness or watering
  • eye itching
  • increased sensitivity of eyes to light
  • weakness
  • dizziness
  • agitation, or
  • hot or cold feeling.

Dosage for Stimate

The recommended dose of Stimate Nasal Spray is to administer one spray per nostril to provide a total dose of 300 mcg.

What Drugs, Substances, or Supplements Interact with Stimate?

Stimate may interact with carbamazepine chlorpromazine lamotrigine oxybutynin vasopressin narcotics antidepressants medicines to treat erectile dysfunction drugs to treat high blood pressure or a prostate disorder beta-blockers or NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use.

Stimate During Pregnancy or Breastfeeding

During pregnancy Stimate should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Stimate (desmopressin acetate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Stimate Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • signs of low sodium--headache, confusion, hallucinations, muscle pain or weakness, drowsiness, vomiting, loss of appetite, and feeling restless or irritable;
  • rapid weight gain, swelling in your feet or ankles;
  • a seizure (convulsions); or
  • nasal problems--runny or stuffy nose, sinus congestion.

Low sodium may be more likely to occur in children and older adults.

Common side effects may include:

  • stuffy nose, runny nose, sinus pain, sneezing, nosebleeds, discomfort in your nose;
  • sore throat, cough;
  • dizziness;
  • increased blood pressure;
  • nausea, stomach cramps;
  • headache, back pain; or
  • flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Stimate (Desmopressin Acetate Nasal Spray)


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Stimate Professional Information


Infrequently, DDAVP® Injection has produced transient headache, nausea, mild abdominal cramps and vulval pain. These symptoms disappeared with reduction in dosage. Occasional facial flushing has been reported with the administration of DDAVP® Injection. Infrequently, high doses of intranasal DDAVP® have produced transient headache and nausea. Nasal congestion, rhinitis and flushing have also been reported occasionally along with mild abdominal cramps. These symptoms disappeared with reduction in dosage. Nosebleed, sore throat, cough and upper respiratory infections have also been reported.

In addition to those listed above, the following have also been reported in clinical trials with Stimate® Nasal Spray: Somnolence, dizziness, itchy or light-sensitive eyes, insomnia, chills, warm feeling, pain, chest pain, palpitations, tachycardia, dyspepsia, edema, vomiting, agitation and balanitis.

DDAVP® Injection (desmopressin acetate) has infrequently produced changes in blood pressure causing either a slight elevation or a transient fall with a compensatory increase in heart rate. Severe allergic reactions including anaphylaxis have been reported rarely with DDAVP® Injection.

Post Marketing

There have been rare reports of convulsions from hyponatremia associated with concomitant use of desmopressin and the following medications: oxybutynin and imipramine. See WARNINGS for the possibility of water intoxication, hyponatremia and coma.

To report SUSPECTED ADVERSE REACTIONS, contact CSL Behring Pharmacovigilance at 1-866-915-6958 or FDA at 1-800-FDA-1088 or www.

Read the entire FDA prescribing information for Stimate (Desmopressin Acetate Nasal Spray)

© Stimate Patient Information is supplied by Cerner Multum, Inc. and Stimate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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