Strattera vs. Dexedrine Spansule, Zenzedi

Are Strattera and Dexedrine Spansule, Zenzedi the Same Thing?

Strattera (atomoxetine) and Dexedrine Spansule or Zenzedi (dextroamphetamine sulfate) are used to treat attention deficit hyperactivity disorder (ADHD).

Dexedrine Spansule or Zenzedi are also used to treat narcolepsy.

Strattera and Dexedrine Spansule or Zenzedi belong to different drug classes. Strattera is a selective norepinephrine reuptake inhibitor (SNRI) and Dexedrine Spansule or Zenzedi are amphetamines.

Side effects of Strattera and Dexedrine Spansule or Zenzedi that are similar include trouble sleeping (insomnia), dry mouth, decreased appetite, upset stomach, dizziness, constipation, impotence, or changes in sex drive.

Side effects of Strattera that are different from Dexedrine Spansule or Zenzedi include cough, nausea or vomiting, drowsiness, irritability, skin rash, itching, increased menstrual cramps, or trouble having an orgasm.

Side effects of Dexedrine Spansule or Zenzedi that are different from Strattera include seizures, blurred vision, rapid heart beat, tremors, headache, weight loss, heart palpitations, elevated blood pressure, overstimulation, restlessness, euphoria, anxiety, involuntary movements, unpleasant taste in mouth, diarrhea, or hives.

What Are Possible Side Effects of Strattera?

Common side effects of Strattera include:

  • trouble sleeping (insomnia),
  • dry mouth,
  • cough,
  • decreased appetite,
  • upset stomach,
  • nausea or vomiting,
  • dizziness,
  • drowsiness,
  • irritability,
  • constipation,
  • skin rash,
  • itching,
  • increased menstrual cramps, and
  • sexual side effects including
    • impotence,
    • loss of interest in sex, or
    • trouble having an orgasm.

What Are Possible Side Effects of Dexedrine Spansule, Zenzedi?

Common side effects of Dexedrine Spansule, Zenzedi include:

  • nausea,
  • stomach upset,
  • cramps,
  • loss of appetite,
  • diarrhea,
  • constipation,
  • dry mouth or unpleasant taste in your mouth,
  • headache,
  • dizziness,
  • nervousness,
  • dizziness,
  • trouble sleeping (insomnia),
  • sweating,
  • weight loss,
  • irritability,
  • restlessness,
  • loss of interest in sex,
  • impotence, or
  • difficulty having an orgasm.

Tell your doctor if you have serious side effects of Dexedrine Spansule including:

  • numbness/pain/skin color change/sensitivity to temperature in the fingers or toes,
  • mental/mood/behavior changes (such as agitation, aggression, mood swings, depression, hallucinations, abnormal thoughts/behavior, thoughts of suicide),
  • uncontrolled movements,
  • muscle twitching or shaking,
  • outbursts of words or sounds,
  • swelling ankles or feet,
  • extreme tiredness,
  • significant unexplained weight loss, or
  • frequent or prolonged erections (in males).

What Is Strattera?

Strattera is a selective norepinephrine reuptake inhibitor medicine. It is used for the treatment of attention deficit and hyperactivity disorder (ADHD). Strattera may help increase attention and decrease impulsiveness and hyperactivity in patients with ADHD.

Strattera should be used as a part of a total treatment program for ADHD that may include counseling or other therapies.

Strattera has not been studied in children less than 6 years old.

What Is Dexedrine Spansule, Zenzedi?

Dexedrine Spansule and Zenzedi are central nervous system stimulants used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).


Who is at greater risk for developing ADHD? See Answer

What Drugs Interact With Strattera?

Tell your doctor about all the medicines that you or your child takes including prescription and nonprescription medicines, vitamins, and herbal supplements. Strattera and some medicines may interact with each other and cause serious side effects. Your doctor will decide whether Strattera can be taken with other medicines.

Especially tell your doctor if you or your child takes:

  • asthma medicines
  • anti-depression medicines including MAOIs
  • blood pressure medicines
  • cold or allergy medicines that contain decongestants

Know the medicines that you or your child takes. Keep a list of your medicines with you to show your doctor and pharmacist.

Do not start any new medicine while taking Strattera without talking to your doctor first.

What Drugs Interact With Dexedrine Spansule, Zenzedi?

Dexedrine Spansule, Zenzedi may interact blood pressure medications, diuretics (water pills), antihistamines, acetazolamide, chlorpromazine, ethosuximide, guanethidine, haloperidol, lithium, methenamine, phenytoin, phenobarbital, sodium bicarbonate (Alka-Seltzer), or antidepressants. Tell your doctor all medications you are taking. Dexedrine should be used only if prescribed during pregnancy. Infants born to mothers who are dependent on this medication may be born too soon (premature) and have low birth weight. They may also have withdrawal symptoms. Tell your doctor if you notice mood changes, agitation, or unusual tiredness in your newborn. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding is not recommended. Dexedrine may be habit-forming. Withdrawal symptoms may occur after stopping this drug.

How Should Strattera Be Taken?

  • Take Strattera exactly as prescribed. Strattera comes in different dose strength capsules. Your doctor may adjust the dose until it is right for you or your child.
  • Do not chew, crush, or open the capsules. Swallow Strattera capsules whole with water or other liquids. Tell your doctor if you or your child cannot swallow Strattera whole. A different medicine may need to be prescribed.
  • Avoid touching a broken Strattera capsule. Wash hands and surfaces that touched an open Strattera capsule. If any of the powder gets in your eyes or your child's eyes, rinse them with water right away and call your doctor.
  • Strattera can be taken with or without food.
  • Strattera is usually taken once or twice a day. Take Strattera at the same time each day to help you remember. If you miss a dose of Strattera, take it as soon as you remember that day. If you miss a day of Strattera, do not double your dose the next day. Just skip the day you missed.
  • From time to time, your doctor may stop Strattera treatment for a while to check ADHD symptoms.
  • Your doctor may do regular checks of the blood, heart, and blood pressure while taking Strattera. Children should have their height and weight checked often while taking Strattera. Strattera treatment may be stopped if a problem is found during these check-ups.
  • If you or your child takes too much Strattera or overdoses, call your doctor or poison control center right away, or get emergency treatment.

How Should Dexedrine Spansule, Zenzedi Be Taken?

The usual dose of Dexedrine Spansule, Zenzedi to treat narcolepsy is 5 to 60 mg per day in divided doses, depending on the patient response. For treatment of ADHD in pediatric patients 6 years of age and older, start with 5 mg once or twice daily; daily dosage may be raised by a physician.


ADHD Symptoms in Children See Slideshow

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FDA. Strattera Product Information.

Arbor Pharmaceuticals, LLC. Zenzedi Product Monograph.

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