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Streptase vs. TNKase

Reviewed on 9/26/2019

Are Streptase and TNKase the Same Thing?

Streptase (streptokinase) and TNKase (tenecteplase) are thrombolytic drugs used in the treatment of heart attack to dissolve unwanted blood clots.

Streptase is also used to help dissolve lung blood clots (pulmonary embolism) as well as leg blood clots (deep venous thrombosis-DVT).

Streptase and TNKase are different types of thrombolytic drugs. Streptase is an enzyme and TNKase is a tissue plasminogen activator (TPA).

The brand name drug Streptase is no longer available in the U.S. Generic forms may be available.

Side effects of Streptase and TNKase that are similar include bleeding (which can include internal bleeding, bleeding in the brain, bleeding from the digestive system, the urinary system, the reproductive system, the lungs, or from parts of the body where needles have been injected or from parts of the body that have had recent surgery), nausea, and dizziness.

Side effects of Streptase that are different from TNKase include headache, low blood pressure, mild fever, rash, itching, flushing, muscle or bone pain, shivering, allergic reactions, and nerve damage.

Both Streptase and TNKase may interact with blood thinners.

Streptase may also interact with nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin.

TNKase may also interact with abciximab, alteplase, anistreplase, dipyridamole, eptifibatide, heparin, streptokinase, tirofiban, and urokinase.

What Are Possible Side Effects of Streptase?

Common side effects of Streptase include:

  • nausea,
  • headache,
  • dizziness,
  • low blood pressure,
  • mild fever,
  • bleeding from wounds or gums,
  • rash,
  • itching,
  • flushing,
  • muscle or bone pain,
  • shivering, and
  • allergic reactions.

Streptase can also cause nerve damage.

What Are Possible Side Effects of TNKase?

Common side effects of TNKase include:

  • bleeding, which can include:
    • internal bleeding,
    • bleeding in the brain,
    • bleeding from the digestive system,
    • the urinary system,
    • the reproductive system,
    • the lungs, or
    • from parts of the body where needles have been injected or from parts of the body that have had recent surgery),
    • nausea, or
    • dizziness

    What Is Streptase?

    Streptase (streptokinase) is an enzyme used in the treatment of heart attack or lung blood clots (pulmonary embolism) as well as leg blood clots (deep venous thrombosis-DVT). The brand name drug Streptase is no longer available in the U.S. Generic versions may be available.

    What Is TNKase?

    TNKase (tenecteplase) is a tissue plasminogen activator (TPA) used to prevent death from a heart attack (acute myocardial infarction). TNKase works by causing the body to over-produce a substance called plasmin to dissolve unwanted blood clots.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

What Drugs Interact With Streptase?

Streptase may interact with blood thinners, non-steroidal anti-inflammatory drugs (NSAIDs), or tnkase. Drugs that can reverse effects of streptokinase include aminocaproic acid, aprotinin, and tranexamic acid. Tell your doctor all medications you are taking.

What Drugs Interact With TNKase?

TNKase may interact with blood thinners, abciximab, alteplase, anistreplase, dipyridamole, eptifibatide, heparin, streptokinase, tirofiban, or urokinase. Tell your doctor all medications and supplements you use.

How Should Streptase Be Taken?

Streptase (streptokinase) is given by injection by a health care professional. Dose is dependent upon the condition of the patient and response to treatment.

How Should TNKase Be Taken?

TNKase is for intravenous administration only. The recommended total dose should not exceed 50 mg and is based upon patient weight.

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References

Medscape. Streptase Drug Information.

https://www.medscape.com/answers/811234-88119/what-is-the-fda-recommended-regimen-of-streptokinase-for-thrombolytic-therapy-of-pulmonary-embolism-pe

Genentech. TNKase Product Information.

https://www.tnkase.com/

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